Establishment and functional characterization of a murine primary Sertoli cell line deficient of connexin43
Sign Up to like & getrecommendations! Published in 2020 at "Cell and Tissue Research"
DOI: 10.1007/s00441-020-03203-y
Abstract: The Sertoli cell (SC) specific connexin43 (Cx43) knockout (SCCx43KO) mouse line is ideal to gain insight into the mechanistic gap junction formation in SC and the seminiferous epithelium. A method for developing primary SC cultures… read more here.
Keywords: connexin43; line; sertoli cell; cx43 ... See more keywords
Connexin43 hemichannel block protects against retinal pigment epithelial cell barrier breakdown
Sign Up to like & getrecommendations! Published in 2019 at "Acta Diabetologica"
DOI: 10.1007/s00592-019-01352-3
Abstract: Aims The retinal pigment epithelium (RPE) is an important component of the outer blood–retinal barrier (BRB) that separates the choroid from the rest of the retina. Loss of RPE-mediated BRB integrity is a key feature… read more here.
Keywords: connexin43; retinal pigment; hemichannel block; connexin43 hemichannel ... See more keywords
Functional consequences of co-expressing connexin40 or connexin45 with connexin43 on intercellular electrical coupling.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.12.169
Abstract: The functional characteristics of the co-expression of connexin43, connexin40, and connexin45 proteins in human myocardium are thought to play an important role in governing normal propagation of the cardiac electrical impulse and in generating the… read more here.
Keywords: connexin40 connexin45; electrical coupling; expression; connexin43 ... See more keywords
Connexin43 regulates osteoprotegerin expression via ERK1/2 -dependent recruitment of Sp1.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.12.173
Abstract: In bone, connexin43 expression in cells of the osteoblast lineage plays an important role in restraining osteoclastogenesis and bone resorption. While there is a consensus around the notion that the anti-osteoclastogenic factor, osteoprotegerin, is a… read more here.
Keywords: connexin43; promoter; expression; sp1 ... See more keywords
Effect of icosapent ethyl on susceptibility to ventricular arrhythmias in postinfarcted rat hearts: Role of GPR120‐mediated connexin43 phosphorylation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15575
Abstract: The ω‐3 fatty acids exert as an antioxidant via the G protein‐coupled receptor 120 (GPR120). Icosapent ethyl, a purified eicosapentaenoic acid, showed a marked reduction in sudden cardiac death. Connexin43 is sensitive to redox status.… read more here.
Keywords: icosapent ethyl; gpr120; connexin43; phosphorylation ... See more keywords
“Orphan” Connexin43 in Plakophilin-2 Deficient Hearts Revealed by Volume Electron Microscopy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.843687
Abstract: Previous studies revealed an abundance of functional Connexin43 (Cx43) hemichannels consequent to loss of plakophilin-2 (PKP2) expression in adult murine hearts. The increased Cx43-mediated membrane permeability is likely responsible for excess entry of calcium into… read more here.
Keywords: electron microscopy; cx43; microscopy; plakophilin ... See more keywords
Gap Junction-Dependent and -Independent Functions of Connexin43 in Biology
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DOI: 10.3390/biology11020283
Abstract: Simple Summary Connexin43 is one of the 21 members of a large protein family that forms intercellular gap junction complexes. It plays a critical role in development by allowing two adjacent cells to exchange cellular… read more here.
Keywords: gap junction; connexin43; junction; independent functions ... See more keywords
Effects of Drugs Formerly Proposed for COVID-19 Treatment on Connexin43 Hemichannels
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23095018
Abstract: Connexin43 (Cx43) hemichannels form a pathway for cellular communication between the cell and its extracellular environment. Under pathological conditions, Cx43 hemichannels release adenosine triphosphate (ATP), which triggers inflammation. Over the past two years, azithromycin, chloroquine,… read more here.
Keywords: cx43 hemichannels; drugs formerly; covid; connexin43 ... See more keywords