Connexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-018-1727-5
Abstract: Diabetic retinopathy (DR) is a vascular disease of the neuroretina characterised by hyperglycaemia and inflammation. Current DR therapies target late-stage vascular defects and there is evidence to suggest that they contribute to geographic atrophy and… read more here.
Keywords: hemichannel block; hemichannel; diabetic retinopathy; connexin43 hemichannel ... See more keywords
Connexin43 hemichannel block protects against retinal pigment epithelial cell barrier breakdown
Sign Up to like & getrecommendations! Published in 2019 at "Acta Diabetologica"
DOI: 10.1007/s00592-019-01352-3
Abstract: Aims The retinal pigment epithelium (RPE) is an important component of the outer blood–retinal barrier (BRB) that separates the choroid from the rest of the retina. Loss of RPE-mediated BRB integrity is a key feature… read more here.
Keywords: connexin43; retinal pigment; hemichannel block; connexin43 hemichannel ... See more keywords
Connexin43 hemichannel block inhibits NLRP3 inflammasome activation in a human retinal explant model of diabetic retinopathy.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108384
Abstract: Diabetic retinopathy (DR), the most common ocular complication associated with diabetes, is a chronic vascular and inflammatory disease that leads to vision loss. The inflammasome pathway, a key part of the innate immune system, is… read more here.
Keywords: nlrp3 inflammasome; model; inflammasome pathway; connexin43 hemichannel ... See more keywords
Orally Delivered Connexin43 Hemichannel Blocker, Tonabersat, Inhibits Vascular Breakdown and Inflammasome Activation in a Mouse Model of Diabetic Retinopathy
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043876
Abstract: Diabetic retinopathy (DR), a microvascular complication of diabetes, is associated with pronounced inflammation arising from the activation of a nucleotide-binding and oligomerization domain-like receptor (NLR) protein 3 (NLRP3) inflammasome. Cell culture models have shown that… read more here.
Keywords: activation; connexin43 hemichannel; inflammasome activation; hemichannel blocker ... See more keywords