Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegenerative disease models
Sign Up to like & getrecommendations! Published in 2017 at "Human Cell"
DOI: 10.1007/s13577-017-0196-4
Abstract: Increasing metabolic syndromes including type-2 diabetes mellitus, obesity, and steatohepatitis are serious problems in most countries in the world. Neurodegenerative diseases such as Alzheimer, Parkinson’s, and Huntington’s diseases are increasing in many countries. However, therapy… read more here.
Keywords: derived alkaloid; plant derived; alkaloid conophylline; activity plant ... See more keywords
Abstract 3968: Conophylline-target ARL6ip1 regulates Ran-mediated cellular migration and invasion in human colorectal cancer cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3968
Abstract: Introduction: Conophylline is an alkaloid isolated from the leaves of Ervatamia microphylla. We isolated conophylline as an inhibitor of K-Ras functions. It is known to ameliorate various disease models in animals, including cancer, diabetes mellitus,… read more here.
Keywords: migration invasion; conophylline; cancer; arl6ip1 ... See more keywords
Direct and Indirect Anticancer Activity of Plant-Derived Alkaloid Conophylline.
Sign Up to like & getrecommendations! Published in 2021 at "Critical reviews in oncogenesis"
DOI: 10.1615/critrevoncog.2020034129
Abstract: K-Ras is one of the most important oncogenes in human oncogenesis. K-Ras transfection of normal rat fibroblasts induces phenotypic change from flat to round morphology. Then, we screened compounds inducing flat morphology in K-Ras transformed… read more here.
Keywords: alkaloid conophylline; plant derived; cancer; conophylline ... See more keywords