Discovery of a Novel Cysteine Framework XXIV Conotoxin from Conus striatus, S24a, with Potential Analgesic Activity
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-020-10109-4
Abstract: A novel conotoxin, S24a, containing 26 amino acid residues was first derived from the cDNA library of Conus striatus . This conotoxin has the same conserved signal peptide as A-superfamily conotoxins and some unconserved residues… read more here.
Keywords: conus striatus; s24a; potential analgesic; conotoxin ... See more keywords
The α9α10 nicotinic acetylcholine receptors antagonist α-conotoxin RgIA reverses colitis signs in murine dextran sodium sulfate model.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173320
Abstract: Nicotinic acetylcholine receptors can regulate inflammation primarily through the vagus nerve via the cholinergic anti-inflammatory pathway. α9α10 nicotinic receptors (nAChRs) are a new promising target for chronic pain and inflammation. Recently, α9α10 selective α-conotoxin antagonists… read more here.
Keywords: nicotinic acetylcholine; colitis; conotoxin; model ... See more keywords
Discovery, Characterization, and Engineering of LvIC, an α4/4-Conotoxin That Selectively Blocks Rat α6/α3β4 Nicotinic Acetylcholine Receptors.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01786
Abstract: α6β4 nicotinic acetylcholine receptors (nAChRs) are expressed in the central and peripheral nervous systems, but their functions are not fully understood, largely because of a lack of specific ligands. Here, we characterized a novel α-conotoxin,… read more here.
Keywords: discovery characterization; acetylcholine receptors; nicotinic acetylcholine; lvic ... See more keywords
Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45466
Abstract: Nicotinic acetylcholine receptors (nAChR) are therapeutic targets for a range of human diseases. α-Conotoxins are naturally occurring peptide antagonists of nAChRs that have been used as pharmacological probes and investigated as drug leads for nAChR… read more here.
Keywords: conotoxin activity; structural mechanisms; nicotinic acetylcholine; conotoxin ... See more keywords
Characterisation of a Novel A-Superfamily Conotoxin
Sign Up to like & getrecommendations! Published in 2020 at "Biomedicines"
DOI: 10.3390/biomedicines8050128
Abstract: Conopeptides belonging to the A-superfamily from the venomous molluscs, Conus, are typically α-conotoxins. The α-conotoxins are of interest as therapeutic leads and pharmacological tools due to their selectivity and potency at nicotinic acetylcholine receptor (nAChR)… read more here.
Keywords: novel superfamily; characterisation novel; framework; superfamily conotoxin ... See more keywords
Comparative Venomics of the Cryptic Cone Snail Species Virroconus ebraeus and Virroconus judaeus
Sign Up to like & getrecommendations! Published in 2022 at "Marine Drugs"
DOI: 10.3390/md20020149
Abstract: The venom duct transcriptomes and proteomes of the cryptic cone snail species Virroconus ebraeus and Virroconus judaeus were obtained and compared. The most abundant and shared conotoxin precursor superfamilies in both species were M, O1,… read more here.
Keywords: cone snail; cryptic cone; conotoxin; snail species ... See more keywords
Conotoxin Patenting Trends in Academia and Industry
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DOI: 10.3390/md20080531
Abstract: Sea snails of the genus Conus produce toxins that have been the subjects of numerous studies, projects, publications, and patents over the years. Since Conus toxins were discovered in the 1960s, their biological activity has… read more here.
Keywords: academia industry; conotoxin; trends academia; patenting trends ... See more keywords
Characterization of the Native Disulfide Isomers of the Novel χ-Conotoxin PnID: Implications for Further Increasing Conotoxin Diversity
Sign Up to like & getrecommendations! Published in 2023 at "Marine Drugs"
DOI: 10.3390/md21020061
Abstract: χ-Conotoxins are known for their ability to selectively inhibit norepinephrine transporters, an ability that makes them potential leads for treating various neurological disorders, including neuropathic pain. PnID, a peptide isolated from the venom of Conus… read more here.
Keywords: native disulfide; disulfide; disulfide isomers; conotoxin ... See more keywords
Loop2 Size Modification Reveals Significant Impacts on the Potency of α-Conotoxin TxID
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DOI: 10.3390/md21050286
Abstract: α4/6-conotoxin TxID, which was identified from Conus textile, simultaneously blocks rat (r) α3β4 and rα6/α3β4 nicotinic acetylcholine receptors (nAChRs) with IC50 values of 3.6 nM and 33.9 nM, respectively. In order to identify the effects… read more here.
Keywords: potency; txid; conotoxin txid; conotoxin ... See more keywords
Novel αO-conotoxin GeXIVA[1,2] Nonaddictive Analgesic with Pharmacokinetic Modelling-Based Mechanistic Assessment
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14091789
Abstract: αO-conotoxin GeXIVA[1,2] was isolated in our laboratory from Conus generalis, a snail native to the South China Sea, and is a novel, nonaddictive, intramuscularly administered analgesic targeting the α9α10 nicotinic acetylcholine receptor (nAChR) with an… read more here.
Keywords: pharmacokinetic modelling; conotoxin; conotoxin gexiva; mechanistic assessment ... See more keywords
Preparation and Functional Identification of a Novel Conotoxin QcMNCL-XIII0.1 from Conus quercinus
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14020099
Abstract: Conotoxins are tools used by marine Conus snails to hunt and are a significant repository for marine drug research. Conotoxins highly selectively coordinate different subtypes of various ion channels, and a few have been used… read more here.
Keywords: qcmncl xiii0; recombinant qcmncl; conus; conotoxin ... See more keywords