Enantioselective Synthesis of Spiro[cyclopentane-1,3'-oxindole] Scaffolds with Five Consecutive Stereocenters.
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DOI: 10.1021/acs.orglett.4c02173
Abstract: A highly diastereo- and enantioselective cascade annulation reaction of Morita-Baylis-Hillman (MBH) maleimides of isatins with ortho-hydroxychalcones was achieved by a chiral N,N'-dioxide/Mg(II) complex Lewis acid catalyst. This strategy provides a concise and efficient route to… read more here.
Keywords: five consecutive; spiro cyclopentane; cyclopentane oxindole; consecutive stereocenters ... See more keywords
Enantioselective Synthesis of Indole-Fused Polycycles Bearing Four Consecutive Stereocenters via Rhodium Catalysis.
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DOI: 10.1021/acs.orglett.4c04814
Abstract: Indole-fused polycycles are common in natural products and bioactive molecules, yet their concise and efficient synthesis remains challenging, especially for compounds with multiple stereocenters. Herein, we report the application of a chiral CpxRhIII catalyst in… read more here.
Keywords: four consecutive; synthesis; consecutive stereocenters; indole fused ... See more keywords