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   Articles with "conserved epitopes" as a keyword



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Highly conserved epitopes of DENV structural and non-structural proteins: Candidates for universal vaccine targets

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recommendations! Published in 2019 at "Gene"

DOI: 10.1016/j.gene.2019.02.001

Abstract: Abstract Dengue is a severe emerging arthropod borne viral disease occurring globally. Around two fifths of the world's population, or up to 3.9 billion people, are at a risk of dengue infection. Infection induces a… read more here.

Keywords: vaccine targets; conserved epitopes; denv structural; epitopes denv ... See more keywords

A Nanoparticle Vaccine Displaying Conserved Epitopes of the Preexisting Neutralizing Antibody Confers Broad Protection against SARS-CoV-2 Variants.

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recommendations! Published in 2024 at "ACS nano"

DOI: 10.1021/acsnano.4c03075

Abstract: The rapid development of the SARS-CoV-2 vaccine has been used to prevent the spread of coronavirus 2019 (COVID-19). However, the ongoing and future pandemics caused by SARS-CoV-2 variants and mutations underscore the need for effective… read more here.

Keywords: sars cov; broad protection; cov variants; conserved epitopes ... See more keywords

Hide and seek: interplay between influenza viruses and B cells.

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recommendations! Published in 2020 at "International immunology"

DOI: 10.1093/intimm/dxaa028

Abstract: Influenza virus constantly acquires genetic mutations/reassortment in the major surface protein, hemagglutinin (HA), resulting in the generation of strains with antigenic variations. There are, however, HA epitopes that are conserved across influenza viruses and are… read more here.

Keywords: conserved epitopes; influenza viruses; influenza; hide seek ... See more keywords

Headless hemagglutinin-containing influenza viral particles direct immune responses toward more conserved epitopes

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recommendations! Published in 2024 at "Journal of Virology"

DOI: 10.1128/jvi.01166-24

Abstract: ABSTRACT Seasonal influenza vaccines provide mostly strain-specific protection due to the elicitation of antibody responses focused on evolutionarily plastic antigenic sites in the hemagglutinin head domain. To direct the humoral response toward more conserved epitopes,… read more here.

Keywords: protection; influenza; response; conserved epitopes ... See more keywords

Long-Term Protection Against Symptomatic Omicron Infections Requires Balanced Immunity Against Spike Epitopes After COVID-19 Vaccination

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recommendations! Published in 2025 at "Vaccines"

DOI: 10.3390/vaccines13080867

Abstract: Background: Systematic studies providing differentiated insight into the contribution of immunity directed against conserved and non-conserved epitopes of SARS-CoV-2 Spike on long-term protection are rare and insufficiently guide future pan-variant vaccine research. The present observational… read more here.

Keywords: protection; immunity; long term; term protection ... See more keywords