Variations outside the conserved motifs of PB1 catalytic active site may affect replication efficiency of the RNP complex of influenza A virus.
Sign Up to like & getrecommendations! Published in 2021 at "Virology"
DOI: 10.1016/j.virol.2021.04.001
Abstract: PB1 functions as the catalytic subunit of influenza virus RNA polymerase complex and plays an essential role in viral RNA transcription and replication. To determine plasticity in the PB1 enzymatic site and map catalytically important… read more here.
Keywords: may affect; conserved motifs; site; influenza virus ... See more keywords
The Significance of Hypervariability and Conserved Motifs in Antimicrobial Peptides from Tree Frogs.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.3c00224
Abstract: Amphibians' skin is a rich source of natural antimicrobial peptides (AMPs). These AMPs exhibit marked inter- and intraspecific sequence divergence linked to the arms race between host and pathogens. Here, we combine peptidomics, molecular modeling,… read more here.
Keywords: significance hypervariability; conserved motifs; antimicrobial peptides; motifs antimicrobial ... See more keywords
Knowledge-guided data mining on the standardized architecture of NRPS: Subtypes, novel motifs, and sequence entanglements
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1011100
Abstract: Non-ribosomal peptide synthetase (NRPS) is a diverse family of biosynthetic enzymes for the assembly of bioactive peptides. Despite advances in microbial sequencing, the lack of a consistent standard for annotating NRPS domains and modules has… read more here.
Keywords: standardized architecture; architecture nrps; conserved motifs; biology ... See more keywords
Genome-Wide Identification of Effector Candidates With Conserved Motifs From the Wheat Leaf Rust Fungus Puccinia triticina
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.01188
Abstract: Rust fungi secrete various specialized effectors into host cells to manipulate the plant defense response. Conserved motifs, including RXLR, LFLAK-HVLVxxP (CRN), Y/F/WxC, CFEM, LysM, EAR, [SG]-P-C-[KR]-P, DPBB_1 (PNPi), and ToxA, have been identified in various… read more here.
Keywords: leaf rust; conserved motifs; rust fungus; effector ... See more keywords