Genome-wide analysis of Indian SARS-CoV-2 genomes to identify T-cell and B-cell epitopes from conserved regions based on immunogenicity and antigenicity
Sign Up to like & getrecommendations! Published in 2021 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2020.107276
Abstract: SARS-CoV-2 has a high transmission rate and shows frequent mutations, thus making vaccine development an arduous task. However, researchers around the globe are working hard to find a solution e.g. synthetic vaccine. Here, we have… read more here.
Keywords: consensus conserved; cell epitopes; cov genomes; sars cov ... See more keywords
Immunogenicity and antigenicity based T-cell and B-cell epitopes identification from conserved regions of 10664 SARS-CoV-2 genomes
Sign Up to like & getrecommendations! Published in 2021 at "Infection, Genetics and Evolution"
DOI: 10.1016/j.meegid.2021.104823
Abstract: The surge of SARS-CoV-2 has created a wave of pandemic around the globe due to its high transmission rate. To contain this virus, researchers are working around the clock for a solution in the form… read more here.
Keywords: cell cell; cell epitopes; cov genomes; sars cov ... See more keywords
Rice black-streaked dwarf virus Genome in China: Diversification, Phylogeny, and Selection.
Sign Up to like & getrecommendations! Published in 2017 at "Plant disease"
DOI: 10.1094/pdis-12-16-1814-re
Abstract: Rice black-streaked dwarf virus (RBSDV), a Fijivirus, causes maize rough dwarf disease and rice black-streaked dwarf disease in the summer maize-growing regions of the Yellow and Huai rivers, respectively, in China. Nevertheless, the diversification and… read more here.
Keywords: black streaked; rbsdv; selection; number ... See more keywords
Limited Recognition of Highly Conserved Regions of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02780-21
Abstract: T cells play a critical role in protection against SARS-CoV-2. Despite being highly topical, the protective role of preexisting preexisting memory CD8+ T cells, induced by prior exposure to circulating common coronavirus strains, remains less… read more here.
Keywords: recognition; regions sars; role; highly conserved ... See more keywords
Abstract 3747: Transcribed ultra-conserved regions (TUCRs): A first computational and molecular characterization of an understudied class of molecules in gliomas
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3747
Abstract: Gliomas are the most common malignant primary brain tumors. Particularly, glioblastoma (GBM) is the most common and deadliest malignant brain tumor. Most glioma research has focused on protein-coding genes and much less on the non-coding… read more here.
Keywords: ultra conserved; understudied class; regions tucrs; conserved regions ... See more keywords
Deregulation of methylation of transcribed-ultra conserved regions in colorectal cancer and their diagnostic and prognostic value.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e15130
Abstract: e15130Background: Expression of Transcribed Ultra Conserved Regions (T-UCRs) is often deregulated in cancer. We investigated the role of three T-UCRs (Uc160, Uc283 and Uc346) in colorectal adenocarcinomas and their prognostic and diagnostic value. Methods: Expression… read more here.
Keywords: methylation; transcribed ultra; colorectal cancer; ultra conserved ... See more keywords
Significance of Conserved Regions in Coronavirus Spike Protein for Developing a Novel Vaccine against SARS-CoV-2 Infection
Sign Up to like & getrecommendations! Published in 2023 at "Vaccines"
DOI: 10.3390/vaccines11030545
Abstract: Over the years, several distinct pathogenic coronaviruses have emerged, including the pandemic SARS-CoV-2, which is difficult to curtail despite the availability of licensed vaccines. The difficulty in managing SARS-CoV-2 is linked to changes in the… read more here.
Keywords: infection; conserved regions; spike protein; significance conserved ... See more keywords
How conserved are the conserved 16S-rRNA regions?
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DOI: 10.7717/peerj.3036
Abstract: The 16S rRNA gene has been used as master key for studying prokaryotic diversity in almost every environment. Despite the claim of several researchers to have the best universal primers, the reality is that no… read more here.
Keywords: conserved conserved; 16s rrna; conserved 16s; rrna gene ... See more keywords