Non-conserved residues dictate dopamine transporter selectivity for the potent synthetic cathinone and psychostimulant MDPV
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108820
Abstract: Clandestine chemists are currently exploiting the pyrrolidinophenone scaffold to develop new designer drugs that carry the risk of abuse and overdose. These drugs promote addiction through the rewarding effects of increased dopaminergic neurotransmission. 3,4-Methylenedioxypyrovalerone (MDPV)… read more here.
Keywords: non conserved; mdpv; dopamine transporter; conserved residues ... See more keywords
Conserved Residues Control the T1R3-Specific Allosteric Signaling Pathway of the Mammalian Sweet-Taste Receptor.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical senses"
DOI: 10.1093/chemse/bjz015
Abstract: Mammalian sensory systems detect sweet taste through the activation of a single heteromeric T1R2/T1R3 receptor belonging to class C G-protein-coupled receptors. Allosteric ligands are known to interact within the transmembrane domain, yet a complete view… read more here.
Keywords: taste receptor; sweet taste; allosteric signaling; conserved residues ... See more keywords
Functional analyses in yeast loss-of-function mutations in conserved residues of BtpB.
Sign Up to like & getrecommendations! Published in 2020 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1007979.s005
Abstract: (A) Alignment of protein sequences of the TIR domains of BtpB, BtpA, human SARM1 and plant RUN1. Conserved residues relevant for this study are marked with the same color code as in Fig 4, except… read more here.
Keywords: loss function; analyses yeast; conserved residues; functional analyses ... See more keywords
Conserved Residues Adjacent to ß-Barrel and Loop Intersection among Enterovirus VP1 Affect Viral Replication: Potential Target for Anti-Enteroviral Development
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14020364
Abstract: Enterovirus genus has over one hundred genotypes and could cause several kinds of severe animal and human diseases. Understanding the role of conserved residues in the VP1 capsid protein among the enterovirus genus may lead… read more here.
Keywords: barrel loop; conserved residues; rgvp1; replication ... See more keywords