Thirteen dubious ways to detect conserved structural RNAs
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DOI: 10.1002/iub.2694
Abstract: Covariation induced by compensatory base substitutions in RNA alignments is a great way to deduce conserved RNA structure, in principle. In practice, success depends on many factors, importantly the quality and depth of the alignment… read more here.
Keywords: rna structure; covariation; conserved rna; thirteen dubious ... See more keywords
The Conserved RNA Binding Cyclophilin, Rct1, Regulates Small RNA Biogenesis and Splicing Independent of Heterochromatin Assembly.
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DOI: 10.1016/j.celrep.2017.05.086
Abstract: RNAi factors and their catalytic activities are essential for heterochromatin assembly in S. pombe. This has led to the idea that siRNAs can promote H3K9 methylation by recruiting the cryptic loci regulator complex (CLRC), also known… read more here.
Keywords: heterochromatin; rna binding; heterochromatin assembly; conserved rna ... See more keywords
Ubiquitin-Proteasome System Regulation of an Evolutionarily Conserved RNA Polymerase II-Associated Factor 1 Involved in Pancreatic Oncogenesis.
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DOI: 10.1021/acs.biochem.7b00865
Abstract: The evolutionarily conserved RNA polymerase II-associated factor 1 (Paf1) from yeast to humans regulates transcription and associated processes, and thus, malfunctions and/or misregulations of Paf1 are associated with cellular pathologies. Indeed, Paf1 (also known as… read more here.
Keywords: evolutionarily conserved; rna polymerase; factor; conserved rna ... See more keywords