Structures of the Human SPAK and OSR1 Conserved C‐Terminal (CCT) Domains **
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DOI: 10.1002/cbic.202100441
Abstract: STE20/SPS1‐related proline/alanine‐rich kinase (SPAK) and oxidative stress responsive 1 (OSR1) kinase are two serine/threonine protein kinases that regulate the function of ion co‐transporters through phosphorylation. The highly conserved C‐terminal (CCT) domains of SPAK and OSR1… read more here.
Keywords: spak osr1; terminal cct; cct; human spak ... See more keywords
Identification of a conserved N‐terminal domain in the first module of ACV synthetases
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DOI: 10.1002/mbo3.1145
Abstract: The l‐δ‐(α‐aminoadipoyl)‐l‐cysteinyl‐d‐valine synthetase (ACVS) is a trimodular nonribosomal peptide synthetase (NRPS) that provides the peptide precursor for the synthesis of β‐lactams. The enzyme has been extensively characterized in terms of tripeptide formation and substrate specificity.… read more here.
Keywords: terminal domain; conserved terminal; first module; domain first ... See more keywords
PorA, a conserved C-terminal domain-containing protein, impacts the PorXY-SigP signaling of the type IX secretion system
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DOI: 10.1038/s41598-020-77987-y
Abstract: Porphyromonas gingivalis, a periodontal pathogen, translocates many virulence factors including the cysteine proteases referred to as gingipains to the cell surface via the type IX secretion system (T9SS). Expression of the T9SS component proteins is… read more here.
Keywords: secretion system; system; conserved terminal; type secretion ... See more keywords