How Frequently Are Pan-Assay Interference Compounds Active? Large-Scale Analysis of Screening Data Reveals Diverse Activity Profiles, Low Global Hit Frequency, and Many Consistently Inactive Compounds.
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DOI: 10.1021/acs.jmedchem.7b00154
Abstract: Undetected pan-assay interference compounds (PAINS) with false-positive activities in assays often propagate through medicinal chemistry programs and compromise their outcomes. Although a large number of PAINS have been classified, often on the basis of individual… read more here.
Keywords: consistently inactive; assay interference; activity profiles; chemistry ... See more keywords