Allogeneic Hematopoietic Cell Transplantation vs Standard Consolidation Chemotherapy in Patients With Intermediate-Risk Acute Myeloid Leukemia: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.7605
Abstract: Importance The ideal postremission strategy in intermediate-risk acute myeloid leukemia (AML) in first complete remission (CR) has been a matter of debate. Objective To explore the optimal therapy for patients with intermediate-risk AML after first… read more here.
Keywords: consolidation chemotherapy; intermediate risk; consolidation; hct ... See more keywords
Intensive consolidation with G‐CSF support: Tolerability, safety, reduced hospitalization, and efficacy in acute myeloid leukemia patients ≥60 years
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DOI: 10.1002/ajh.24847
Abstract: The aim of this study was to evaluate the efficacy and feasibility of intensified consolidation therapy employing fludarabine and ARA-C in cycle 1 and intermediate-dose ARA-C (IDAC) in cycles 2 through 4, in elderly acute… read more here.
Keywords: consolidation; hospitalization; myeloid leukemia; efficacy ... See more keywords
Contextual fear conditioning with a time interval induces CREB phosphorylation in the dorsal hippocampus and amygdala nuclei that depend on prelimbic cortex activity.
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DOI: 10.1002/hipo.23516
Abstract: In temporal associations, a conditioned stimulus (CS) is separated by a time interval from the unconditioned stimulus (US), which activates the prelimbic cortex (PL) to maintain a CS representation over time. However, it is unknown… read more here.
Keywords: time interval; consolidation; hippocampus; activity ... See more keywords
Autologous hematopoietic cell transplantation versus whole‐brain radiotherapy consolidation in primary central nervous system lymphoma: A systematic review and meta‐analysis
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DOI: 10.1002/hon.3083
Abstract: The management of newly diagnosed primary central nervous system lymphoma (PCNSL) includes administration of high‐dose methotrexate based regimens followed by consolidation therapy to minimize the risk of relapse. However, the best consolidation strategy (autologous hematopoietic… read more here.
Keywords: meta analysis; consolidation; auto hct;
SAFETY AND EFFICACY OF THE “CARMEN” REGIMEN, A NEW DOSE‐DENSE SHORT‐TERM THERAPY IN PATIENTS WITH AGGRESSIVE B‐CELL LYMPHOMA AND MYC REARRANGEMENT
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DOI: 10.1002/hon.93_2880
Abstract: Introduction: Patients (pts) with aggressive B-cell lymphoma and MYC rearrangement exhibits poor outcome after R-CHOP treatment. In the last decade, these pts were treated with a new dose-dense, short-term therapy termed “CARMEN”, at several Italian… read more here.
Keywords: hgbcl pts; myc rearrangement; consolidation; induction ... See more keywords
The mTORC1 inhibitor rapamycin and the mTORC1/2 inhibitor AZD2014 impair the consolidation and persistence of contextual fear memory
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05573-1
Abstract: The mechanistic target of rapamycin (mTOR) kinase mediates various long-lasting forms of synaptic and behavioural plasticity. However, there is little information concerning the temporal pattern of mTOR activation and susceptibility to pharmacological intervention during consolidation… read more here.
Keywords: consolidation; inhibitor; fear memory; persistence ... See more keywords
Rottlerin, BDNF, and the impairment of inhibitory avoidance memory.
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05690-x
Abstract: RATIONALE AND OBJECTIVE As a eukaryotic elongation factor 2 kinase (eEF2K) inhibitor and a mitochondrial uncoupler, oncologists have extensively studied rottlerin. Neuroscientists, however, have accumulated scarce data on the role of rottlerin in affective and… read more here.
Keywords: consolidation; inhibitory avoidance; rottlerin; memory ... See more keywords
Thiotepa, busulfan, and cyclophosphamide or busulfan, cyclophosphamide, and etoposide high-dose chemotherapy followed by autologous stem cell transplantation for consolidation of primary central nervous system lymphoma
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DOI: 10.1007/s00277-019-03667-1
Abstract: Primary central nervous system lymphoma (PCNSL) is a rare extranodal non-Hodgkin lymphoma for which standard treatment has yet to be established. High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is a suitable consolidation strategy… read more here.
Keywords: chemotherapy; busulfan; consolidation; primary central ... See more keywords
Antibiotic use during cytarabine consolidation in acute myeloid leukemia
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DOI: 10.1007/s00277-020-04238-5
Abstract: Acute myeloid leukemia (AML) patients undergoing consolidation chemotherapy with intermediate or high-dose cytarabine (IDAC/HiDAC) are often placed on prophylactic antibacterials. This practice is largely based on the benefits of prophylaxis (PPX) during induction chemotherapy. However,… read more here.
Keywords: idac hidac; consolidation; myeloid leukemia; cytarabine ... See more keywords
The role of novel agents for consolidation after autologous transplantation in newly diagnosed multiple myeloma: a systematic review
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DOI: 10.1007/s00277-020-04316-8
Abstract: Despite the increasing inclusion of novel agents within the multiple myeloma (MM) treatment sequence, their role for posttransplant consolidation therapy remains unclear. We systematically reviewed studies evaluating the efficacy of novel agent consolidation. We identified… read more here.
Keywords: consolidation therapy; consolidation; novel agents; multiple myeloma ... See more keywords
Radiographic findings in 240 patients with COVID-19 pneumonia: time-dependence after the onset of symptoms
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DOI: 10.1007/s00330-020-06967-7
Abstract: To analyze the most frequent radiographic features of COVID-19 pneumonia and assess the effectiveness of chest X-ray (CXR) in detecting pulmonary alterations. CXR of 240 symptomatic patients (70% male, mean age 65 ± 16 years), with SARS-CoV-2… read more here.
Keywords: 240 patients; consolidation; covid pneumonia; group group ... See more keywords