Molecular Origin of the Stability Difference in Four Shark IgNAR Constant Domains.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.04.013
Abstract: Improving the stability of antibodies for manufacture and shelf life is one of the main focuses of antibody engineering. One stabilization strategy is to perform specific mutations in human antibodies based on highly stable antibodies… read more here.
Keywords: molecular origin; constant domains; four shark; stability ... See more keywords
Switching Heavy Chain Constant Domains Denatures the Paratope 3D Architecture of Influenza Monoclonal Antibodies
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens"
DOI: 10.3390/pathogens12010051
Abstract: Several human monoclonal Abs for treating Influenza have been evaluated in clinical trials with limited success despite demonstrating superiority in preclinical animal models including mice. To conduct efficacy studies in mice, human monoclonal Abs are… read more here.
Keywords: heavy chain; mouse; constant domains; chain constant ... See more keywords