Constitutional mutations of the CHEK2 gene are a risk factor for MDS, but not for de novo AML.
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DOI: 10.1016/j.leukres.2018.05.013
Abstract: CHEK2 plays a key role in cellular response to DNA damage, and also in regulation of mitosis and maintenance of chromosomal stability. In patients newly diagnosed with myelodysplastic syndrome (MDS, n = 107) or acute myeloid leukemia… read more here.
Keywords: mutations chek2; risk; constitutional mutations; chek2 ... See more keywords