Constitutive activation of β-catenin in odontoblasts induces aberrant pulp calcification in mouse incisors.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular histology"
DOI: 10.1007/s10735-021-09965-1
Abstract: During dentin formation, odontoblast polarization ensures that odontoblasts directionally secrete dentin matrix protein, leading to tubular dentin formation; however, little is known about the major features and regulatory mechanisms of odontoblast polarization. In a study… read more here.
Keywords: dentin; catenin; polarization; odontoblast polarization ... See more keywords
Adult-Onset Myopathy with Constitutive Activation of Akt following the Loss of hnRNP-U
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101319
Abstract: Summary Skeletal muscle has the remarkable ability to modulate its mass in response to changes in nutritional input, functional utilization, systemic disease, and age. This is achieved by the coordination of transcriptional and post-transcriptional networks… read more here.
Keywords: adult onset; activation akt; muscle; constitutive activation ... See more keywords
Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium
Sign Up to like & getrecommendations! Published in 2017 at "Redox Biology"
DOI: 10.1016/j.redox.2017.04.038
Abstract: Redox homeostasis regulates key cellular signaling pathways in both physiology and pathology. The cell's antioxidant response provides a defense against oxidative stress and establishes a redox tone permissive for cell signaling. The molecular regulation of… read more here.
Keywords: state; redox homeostasis; antioxidant response; nrf2 ... See more keywords
IGF1R constitutive activation expands luminal progenitors and influences lineage differentiation during breast tumorigenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental biology"
DOI: 10.1016/j.ydbio.2020.04.007
Abstract: Breast tumors display tremendous heterogeneity in part due to varying molecular alterations, divergent cells of origin, and differentiation. Understanding where and how this heterogeneity develops is likely important for effective breast cancers eradication. Insulin-like growth… read more here.
Keywords: lineage differentiation; differentiation; constitutive activation; igf1r constitutive ... See more keywords
Structural Determinants of Constitutive Activation of Gα Proteins: Transducin as a Paradigm.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.6b00813
Abstract: Heterotrimeric guanine nucleotide-binding proteins (Gα proteins) are intracellular nanomachines deputed to signal transduction. The switch-on process requires the release of bound GDP from a site at the interface between GTPase and helical domains. Nucleotide release… read more here.
Keywords: collective motions; nucleotide binding; determinants constitutive; constitutive activation ... See more keywords
Constitutive Activation of the Human Aryl Hydrocarbon Receptor in Mice Promotes Hepatocarcinogenesis Independent of Its Coactivator Gadd45b
Sign Up to like & getrecommendations! Published in 2019 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfy263
Abstract: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or dioxin, is a potent liver cancer promoter through its sustained activation of the aryl hydrocarbon receptor (Ahr) in rodents. However, the carcinogenic effect of TCDD and AHR in humans has been controversial.… read more here.
Keywords: ahr; activation human; human ahr; constitutive activation ... See more keywords
Constitutive Activation of MexT by Amino Acid Substitutions Results in MexEF-OprN Overproduction in Clinical Isolates of Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02445-17
Abstract: ABSTRACT When overproduced, the multidrug efflux system MexEF-OprN increases the resistance of Pseudomonas aeruginosa to fluoroquinolones, chloramphenicol, and trimethoprim. In this work, we demonstrate that gain-of-function mutations in the regulatory gene mexT result in oligomerization… read more here.
Keywords: pseudomonas aeruginosa; activation mext; constitutive activation; clinical isolates ... See more keywords
Constitutive Activation of β-Catenin in Differentiated Osteoclasts Induces Bone Loss in Mice
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000492549
Abstract: Background/Aims: Activation of the Wnt/β-catenin signalling pathway has been widely investigated in bone biology and shown to promote bone formation. However, its specific effects on osteoclast differentiation have not been fully elucidated. Our study aimed… read more here.
Keywords: catenin; activation catenin; bone; constitutive activation ... See more keywords
Constitutive Activation of gp130 in T Cells Results in Senescence and Premature Aging.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of immunology"
DOI: 10.4049/jimmunol.2200788
Abstract: IL-6 family members contribute to host defense through the stimulation of acute-phase signaling, hematopoiesis, immune reactions, and regenerative processes. To investigate essential mechanisms that are linked toward a constitutively activated gp130 signaling, we generated and… read more here.
Keywords: cell; gp130 cells; activation gp130; gp130 ... See more keywords