CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2
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DOI: 10.1126/scisignal.aaw2040
Abstract: CDK5 inhibits constitutive internalization of the nociceptor TRPV1 and contributes to inflammatory hyperalgesia. Constitutive internalization of a nociceptor The nonselective cation channel TRPV1 elicits the sensation of burning pain in response to thermal or chemical… read more here.
Keywords: trpv1; adaptor protein; internalization; ap2 ... See more keywords