The chloride intracellular channel protein CLIC4 inhibits filopodium formation induced by constitutively active mutants of formin mDia2
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13766
Abstract: Chloride intracellular channel 4 (CLIC4) functions in diverse actin‐dependent processes. Upon Rho activation, CLIC4 reversibly translocates from the cytosol to the plasma membrane to regulate cell adhesion and migration. At the plasma membrane, CLIC4 counters… read more here.
Keywords: chloride intracellular; mdia2; constitutively active; intracellular channel ... See more keywords
On the design of a constitutively active peptide asparaginyl ligase for facile protein conjugation.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13575
Abstract: Peptide asparaginyl ligases (PALs) are precision tools for peptide cyclization, cell‐surface labelling, protein semisynthesis and protein conjugation. PALs are expressed as inactive proenzymes requiring low pH activation. During activation, a large portion of the cap… read more here.
Keywords: ligase; peptide asparaginyl; protein conjugation; constitutively active ... See more keywords
Constitutively active Rheb mutants [T23M] and [E40K] drive increased production and secretion of recombinant protein in Chinese hamster ovary cells
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27748
Abstract: Monoclonal antibodies (mAbs) are high value agents used for disease therapy (“biologic drugs”) or as diagnostic tools which are widely used in the healthcare sector. They are generally manufactured in mammalian cells, in particular Chinese… read more here.
Keywords: protein; constitutively active; rheb; chinese hamster ... See more keywords
Overexpression of Drosophila NUAK or Constitutively‐Active Formin‐Like Promotes the Formation of Aberrant Myofibrils
Sign Up to like & getrecommendations! Published in 2025 at "Cytoskeleton"
DOI: 10.1002/cm.21999
Abstract: Muscle development and maintenance is central to the normal functioning of animals. Muscle tissues exhibit high levels of activity and require the dynamic turnover of proteins. An actomyosin scaffold functions with additional proteins comprising the… read more here.
Keywords: drosophila nuak; constitutively active; nuak; formin like ... See more keywords
Modulation of the humoral immune response by constitutively active STAT6 expression in murine B cells
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201948313
Abstract: The transcription factor STAT6 regulates gene expression in response to IL‐4 and IL‐13. To further investigate how activated STAT6 modulates B cells development and function in vivo, we characterized mice that express a constitutively active… read more here.
Keywords: cd19cre stat6vt; response; constitutively active; expression ... See more keywords
Overexpression of Constitutively Active OsRab11 in Plants Enhances Tolerance to High Salinity Levels
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Plant Biology"
DOI: 10.1007/s12374-018-0048-0
Abstract: Rab proteins are key regulators of intracellular trafficking between specific compartments in a cell. Among them, Rab11, a widely conserved sub-group, mainly regulates plasma membrane (PM) trafficking. Previously, we reported that Oryza sativa Rab11 (OsRab11)… read more here.
Keywords: osrab11; constitutively active; tolerance high; stress ... See more keywords
Cardioprotective effects of constitutively active MEK1 against H2O2-induced apoptosis and autophagy in cardiomyocytes via the ERK1/2 signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.03.008
Abstract: Oxidative stress injury is one of the main mechanisms of ischemia-reperfusion (I/R) injury. The extracellular signal-regulated kinase (ERK1/2) pathway plays an important role in cardioprotective during acute myocardial infarction. In this study, we used constitutively… read more here.
Keywords: apoptosis; camek; constitutively active; h2o2 ... See more keywords
A constitutively-active IKK-complex at the axon initial segment
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2017.10.020
Abstract: BACKGROUND Previous studies provided evidence for an accumulation of IκB-kinase (IKK) α/β at the axon initial segment (AIS), a neuronal compartment defined by ankyrin-G expression. Here we explored whether the presence of the IKK-complex at… read more here.
Keywords: initial segment; axon initial; constitutively active; ikk ... See more keywords
Induction of resveratrol biosynthesis in Vitis amurensis cells by heterologous expression of the Arabidopsis constitutively active, Ca2+-independent form of the AtCPK1 gene
Sign Up to like & getrecommendations! Published in 2017 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2016.12.026
Abstract: Abstract In the present study, we established transgenic calli of Vitis amurensis that expressed a constitutively active, Ca2+-independent form of the AtCPK1 gene (AtCPK1-Ca) and calli with a non-active form of the gene. High-performance liquid… read more here.
Keywords: resveratrol; form; constitutively active; expression ... See more keywords
Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c09694
Abstract: Parathyroid hormone 1 receptor (PTH1R) plays a key role in mediating calcium homeostasis and bone development, and aberrant PTH1R activity underlies several human diseases. Peptidic PTH1R antagonists and inverse agonists have therapeutic potential in treating… read more here.
Keywords: active pth1r; constitutively active; pth1r; backbone modification ... See more keywords
A Reciprocal Interaction between β-Catenin and Osterix in Cementogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08607-5
Abstract: Although accumulating evidence indicates that both β-catenin and osterix (Osx) are essential for bone and tooth development, few studies have investigated the interaction of these two key proteins in the context of cementogenesis. In this… read more here.
Keywords: tcf lef; cementogenesis; catenin; constitutively active ... See more keywords