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Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13766
Abstract: Chloride intracellular channel 4 (CLIC4) functions in diverse actin‐dependent processes. Upon Rho activation, CLIC4 reversibly translocates from the cytosol to the plasma membrane to regulate cell adhesion and migration. At the plasma membrane, CLIC4 counters…
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Keywords:
chloride intracellular;
mdia2;
constitutively active;
intracellular channel ... See more keywords
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Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13575
Abstract: Peptide asparaginyl ligases (PALs) are precision tools for peptide cyclization, cell‐surface labelling, protein semisynthesis and protein conjugation. PALs are expressed as inactive proenzymes requiring low pH activation. During activation, a large portion of the cap…
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Keywords:
ligase;
peptide asparaginyl;
protein conjugation;
constitutively active ... See more keywords
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Published in 2021 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27748
Abstract: Monoclonal antibodies (mAbs) are high value agents used for disease therapy (“biologic drugs”) or as diagnostic tools which are widely used in the healthcare sector. They are generally manufactured in mammalian cells, in particular Chinese…
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Keywords:
protein;
constitutively active;
rheb;
chinese hamster ... See more keywords
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Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201948313
Abstract: The transcription factor STAT6 regulates gene expression in response to IL‐4 and IL‐13. To further investigate how activated STAT6 modulates B cells development and function in vivo, we characterized mice that express a constitutively active…
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Keywords:
cd19cre stat6vt;
response;
constitutively active;
expression ... See more keywords
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Published in 2018 at "Journal of Plant Biology"
DOI: 10.1007/s12374-018-0048-0
Abstract: Rab proteins are key regulators of intracellular trafficking between specific compartments in a cell. Among them, Rab11, a widely conserved sub-group, mainly regulates plasma membrane (PM) trafficking. Previously, we reported that Oryza sativa Rab11 (OsRab11)…
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Keywords:
osrab11;
constitutively active;
tolerance high;
stress ... See more keywords
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Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.03.008
Abstract: Oxidative stress injury is one of the main mechanisms of ischemia-reperfusion (I/R) injury. The extracellular signal-regulated kinase (ERK1/2) pathway plays an important role in cardioprotective during acute myocardial infarction. In this study, we used constitutively…
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Keywords:
apoptosis;
camek;
constitutively active;
h2o2 ... See more keywords
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Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2017.10.020
Abstract: BACKGROUND Previous studies provided evidence for an accumulation of IκB-kinase (IKK) α/β at the axon initial segment (AIS), a neuronal compartment defined by ankyrin-G expression. Here we explored whether the presence of the IKK-complex at…
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Keywords:
initial segment;
axon initial;
constitutively active;
ikk ... See more keywords
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Published in 2017 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2016.12.026
Abstract: Abstract In the present study, we established transgenic calli of Vitis amurensis that expressed a constitutively active, Ca2+-independent form of the AtCPK1 gene (AtCPK1-Ca) and calli with a non-active form of the gene. High-performance liquid…
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Keywords:
resveratrol;
form;
constitutively active;
expression ... See more keywords
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Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08607-5
Abstract: Although accumulating evidence indicates that both β-catenin and osterix (Osx) are essential for bone and tooth development, few studies have investigated the interaction of these two key proteins in the context of cementogenesis. In this…
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Keywords:
tcf lef;
cementogenesis;
catenin;
constitutively active ... See more keywords
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Published in 2020 at "Human molecular genetics"
DOI: 10.1093/hmg/ddaa008
Abstract: Rhodopsin is the G protein-coupled receptor in rod photoreceptor cells that initiates vision upon photon capture. The light receptor is normally locked in an inactive state in the dark by the covalently bound inverse agonist…
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Keywords:
rhodopsin;
constitutively active;
retinal degeneration;
night blindness ... See more keywords
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Published in 2020 at "International immunology"
DOI: 10.1093/intimm/dxaa073
Abstract: MDA5 is a cytoplasmic sensor of viral RNA, triggering type-I interferon (IFN-I) production. Constitutively active MDA5 has been linked to autoimmune diseases such as systemic lupus erythematosus, Singleton-Merten syndrome (SMS), and Aicardi-Goutières syndrome (AGS), a…
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Keywords:
aicardi gouti;
constitutively active;
encephalitis;
active mda5 ... See more keywords