Constrained instruments and their application to Mendelian randomization with pleiotropy
Sign Up to like & getrecommendations! Published in 2019 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22184
Abstract: In Mendelian randomization (MR), inference about causal relationship between a phenotype of interest and a response or disease outcome can be obtained by constructing instrumental variables from genetic variants. However, MR inference requires three assumptions,… read more here.
Keywords: pleiotropy; mendelian randomization; genetic variants; instrumental variables ... See more keywords