Substitution Rates Predicted by Stability‐Constrained Models of Protein Evolution Are Not Consistent with Empirical Data
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msx327
Abstract: &NA; Protein structures strongly influence molecular evolution. In particular, the evolutionary rate of a protein site depends on the number of its native contacts. Stability‐constrained models of protein evolution consider this influence of protein structure… read more here.
Keywords: evolution; protein evolution; stability; constrained models ... See more keywords
Kinetically constrained models constructed from dissipative quantum dynamics
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DOI: 10.1103/physrevb.110.014301
Abstract: We propose a construction of kinetically constrained models using the Markovian quantum dynamics under strong dissipation. Engineering the Gorini-Kossakowski-Sudarshan-Lindblad (GKSL) equation through classical noise, we show that strong dissipation leads to the emergent decoherence-free subspaces,… read more here.
Keywords: kinetically constrained; constrained models; models constructed; quantum dynamics ... See more keywords
Enzyme‐constrained models predict the dynamics of Saccharomyces cerevisiae growth in continuous, batch and fed‐batch bioreactors
Sign Up to like & getrecommendations! Published in 2022 at "Microbial Biotechnology"
DOI: 10.1111/1751-7915.13995
Abstract: Genome‐scale, constraint‐based models (GEM) and their derivatives are commonly used to model and gain insights into microbial metabolism. Often, however, their accuracy and predictive power are limited and enable only approximate designs. To improve their… read more here.
Keywords: batch; growth; models predict; enzyme constrained ... See more keywords