Chemically Diverse Helix-Constrained Peptides Using Selenocysteine Crosslinking.
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DOI: 10.1021/acs.orglett.8b00233
Abstract: The use of selenocysteines and various cross-linkers to induce helicity in a bioactive peptide is described. The higher reactivity of selenocysteine, relative to cysteine, facilitates rapid cross-linking within unprotected linear peptides under mild aqueous conditions.… read more here.
Keywords: using selenocysteine; chemically diverse; diverse helix; helix constrained ... See more keywords
Selection for constrained peptides that bind to a single target protein
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DOI: 10.1038/s41467-021-26350-4
Abstract: Peptide secondary metabolites are common in nature and have diverse pharmacologically-relevant functions, from antibiotics to cross-kingdom signaling. Here, we present a method to design large libraries of modified peptides in Escherichia coli and screen them… read more here.
Keywords: protein; target; selection; bind single ... See more keywords
β-Ginkgotides: Hyperdisulfide-constrained peptides from Ginkgo biloba
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DOI: 10.1038/s41598-017-06598-x
Abstract: Hyperdisulfide-constrained peptides are distinguished by their high stability and diverse functions. Thus far, these peptides have been reported from animals only but their occurrence in plants are rare. Here, we report the discovery, synthesis and… read more here.
Keywords: ginkgo biloba; ginkgotides hyperdisulfide; peptides ginkgo; hyperdisulfide constrained ... See more keywords
Achieving enhanced cell penetration of short conformationally constrained peptides through amphiphilicity tuning† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc03614k
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DOI: 10.1039/c7sc03614k
Abstract: We synthesized a panel of conformationally constrained peptides with either α-helix or β-hairpin conformations. We tuned the amphiphilicity of these constrained peptides with different distributions of charged or hydrophobic residues and compared their cellular uptake… read more here.
Keywords: amphiphilicity; conformationally constrained; enhanced cell; constrained peptides ... See more keywords
Constrained peptides mimic a viral suppressor of RNA silencing
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DOI: 10.1093/nar/gkab1149
Abstract: Abstract The design of high-affinity, RNA-binding ligands has proven very challenging. This is due to the unique structural properties of RNA, often characterized by polar surfaces and high flexibility. In addition, the frequent lack of… read more here.
Keywords: constrained peptides; rna silencing; suppressor rna; rna ... See more keywords