Nature of Long-Range Evolutionary Constraint in Enzymes: Insights from Comparison to Pseudoenzymes with Similar Structures
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DOI: 10.1093/molbev/msy177
Abstract: Enzymes are known to fine-tune their sequences to optimize catalytic function, yet quantitative evolutionary design principles of enzymes remain elusive on the proteomic scale. Recently, it was found that the catalytic site in enzymes induces… read more here.
Keywords: constraint enzymes; evolutionary constraint; long range; range evolutionary ... See more keywords