Constraints Shape Cell Function and Morphology by Canalizing the Developmental Path along the Waddington's Landscape
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DOI: 10.1002/bies.201900108
Abstract: Studies performed in absence of gravitational constraint show that a living system is unable to choose between two different phenotypes, thus leading cells to segregate into different, alternative stable states. This finding demonstrates that the… read more here.
Keywords: morphology canalizing; function morphology; cell function; shape cell ... See more keywords
Cognitive Constraints Shape Public Debate on the Risks of Synthetic Biology.
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DOI: 10.1016/j.tibtech.2018.09.002
Abstract: We consider efforts to understand public perceptions of synthetic biology, describing a novel cognitive science approach indicating that cognitive biases constrain risk perceptions of synthetic biology. We discuss the implications of these findings and outline… read more here.
Keywords: public debate; synthetic biology; cognitive constraints; constraints shape ... See more keywords
Competing constraints shape the nonequilibrium limits of cellular decision-making
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2022.07.01.498451
Abstract: Gene regulation is central to cellular function. Yet, despite decades of work, we lack quantitative models that can predict how transcriptional control emerges from molecular interactions at the gene locus. Thermodynamic models of transcription, which… read more here.
Keywords: transcription; energy; constraints shape; interference ... See more keywords