Paeonol inhibits chronic constriction injury‐induced astrocytic activation and neuroinflammation in rats via the HDAC/miR‐15a pathway
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DOI: 10.1002/ddr.21993
Abstract: Neuropathic pain affects millions of people in the worldwide, but the major therapeutics perform limited effectiveness. Paeonol (PAE) is widely distributed in Paeonis albiflora, and has manifested anti‐inflammatory and antioxidative effects in multiple diseases. The… read more here.
Keywords: hdac mir; paeonol; astrocytic activation; constriction injury ... See more keywords
Chronic constriction injury of the sciatic nerve in rats causes different activation modes of microglia between the anterior and posterior horns of the spinal cord
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2020.104672
Abstract: Chronic constriction injury of the sciatic nerve is frequently considered as a cause of chronic neuropathic pain. Marked activation of microglia in the posterior horn (PH) has been well established with regard to this pain.… read more here.
Keywords: activation modes; modes microglia; chronic constriction; activation ... See more keywords
Comparison of sildenafil, fluoxetine and its co-administration against chronic constriction injury induced neuropathic pain in rats: An influential additive effect
Sign Up to like & getrecommendations! Published in 2019 at "Neurological Research"
DOI: 10.1080/01616412.2019.1630091
Abstract: ABSTRACT Current drug treatment available for neuropathic pain (NP) provides meager and partial pain relief due to incomplete efficacy and dose-dependent adverse effect. Hence, combination therapy can provide prolongation in analgesic effect with milder side… read more here.
Keywords: sildenafil fluoxetine; effect; chronic constriction; neuropathic pain ... See more keywords
IL-6 contributes to Nav1.3 up-regulation in trigeminal nerve following chronic constriction injury
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DOI: 10.1080/01616412.2020.1747719
Abstract: ABSTRACT Background: To verify the hypothesis that the nature of trigeminal neuralgia (TN) is an ectopic impulse induced by sodium channel modulated by cytokines, we conducted an animal study using the infraorbital nerve chronic constriction… read more here.
Keywords: trigeminal nerve; group; chronic constriction; cci group ... See more keywords
Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats
Sign Up to like & getrecommendations! Published in 2022 at "Channels"
DOI: 10.1080/19336950.2021.2023383
Abstract: ABSTRACT The voltage-gated sodium channel isoform NaV1.7 is a critical player in the transmission of nociceptive information. This channel has been heavily implicated in human genetic pain disorders and is a validated pain target. However,… read more here.
Keywords: small molecule; chronic constriction; constriction injury; injury ... See more keywords
Effects of microRNA-223 on morphine analgesic tolerance by targeting NLRP3 in a rat model of neuropathic pain
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DOI: 10.1177/1744806917706582
Abstract: Objective To investigate the effects of microRNA-223 on morphine analgesic tolerance by targeting NLRP3 in a rat model of neuropathic pain. Methods Our study selected 100 clean grade healthy Sprague-Dawley adult male rats weighing 200… read more here.
Keywords: 223 morphine; morphine; chronic constriction; mir 223 ... See more keywords
Astrocyte-microglia interaction through C3/C3aR pathway modulates neuropathic pain in rats model of chronic constriction injury
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DOI: 10.1177/17448069221140532
Abstract: Neuropathic pain (NP) is the cardinal symptom of neural injury, and its underlying molecular mechanism needs further investigation. Complements, especially complement 3 (C3), are involved in the pathophysiology of many neurological disorders, while the specific… read more here.
Keywords: constriction injury; neuropathic pain; pain; c3ar ... See more keywords
Identification of potential key circular RNAs related to cognitive impairment after chronic constriction injury of the sciatic nerve
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.925300
Abstract: Chronic neuropathic pain is commonly accompanied by cognitive impairment. However, the underlying mechanism in the occurrence of cognitive deficits under constant nociceptive irritation remains elusive. Herein, we established a chronic neuropathic pain model by chronic… read more here.
Keywords: sciatic nerve; impairment; cognitive impairment; constriction injury ... See more keywords
Analgesic Action of Catechin on Chronic Constriction Injury–Induced Neuropathic Pain in Sprague–Dawley Rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.895079
Abstract: Chronic neuropathy is a common and debilitating problem that poses a significant challenge to health care worldwide. Natural compounds have received considerable attention as potential sources of new drugs for the treatment of neuropsychiatric pain.… read more here.
Keywords: constriction injury; chronic constriction; neuropathic pain; pain ... See more keywords
Downregulation of nuclear STAT2 protein in the spinal dorsal horn is involved in neuropathic pain following chronic constriction injury of the rat sciatic nerve
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1069331
Abstract: Regulation of gene transcription in the spinal dorsal horn (SDH) plays a critical role in the pathophysiology of neuropathic pain. In this study, we investigated whether the transcription factor STAT2 affects neuropathic pain and evaluated… read more here.
Keywords: stat2; constriction injury; neuropathic pain; pain ... See more keywords
Kaurenoic Acid Reduces Ongoing Chronic Constriction Injury-Induced Neuropathic Pain: Nitric Oxide Silencing of Dorsal Root Ganglia Neurons
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DOI: 10.3390/ph16030343
Abstract: Kaurenoic acid (KA) is a diterpene extracted from Sphagneticola trilobata (L.) Pruski. KA presents analgesic properties. However, the analgesic activity and mechanisms of action of KA in neuropathic pain have not been investigated so far;… read more here.
Keywords: nitric oxide; constriction injury; neuropathic pain; pain ... See more keywords