NHC-Catalyzed Enantioselective [3 + 3] Annulation to Construct 5,6-Dihydropyrimidin-4-ones.
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DOI: 10.1021/acs.orglett.0c02832
Abstract: The unprecedented enantioselective NHC-catalyzed [3 + 3] annulation of α-bromoenals with amidines via a dual C-N bond formation is described. The protocol allows a rapid preparation of 5,6-dihydropyrimidinones in acceptable yields with good enantioselectivities. read more here.
Keywords: annulation; construct dihydropyrimidin; nhc catalyzed; catalyzed enantioselective ... See more keywords