Asymmetric construction of dihydrobenzofuran-2,5-dione derivatives via desymmetrization of p-quinols with azlactones.
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DOI: 10.1039/c8cc08985j
Abstract: The desymmetrization of p-quinols through a chiral bisguanidinium hemisalt catalyzed enantioselective Michael addition/lactonization cascade reaction with azlactones was reported. 3-Amino-benzofuran-2,5-diones containing a chiral amino acid residue were achieved with up to 99% ee and >19 : 1… read more here.
Keywords: construction dihydrobenzofuran; dihydrobenzofuran dione; desymmetrization quinols; asymmetric construction ... See more keywords