Construction of Distant Stereocenters by Enantioselective Desymmetrizing Carbonyl-Ene Reaction.
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DOI: 10.1021/acs.orglett.7b01329
Abstract: An efficient desymmetrizing carbonyl-ene reaction of 1-substituted 4-methylenecyclohexanes with glyoxal derivatives was thus executed by a chiral N,N'-dioxide/NiII catalyst, providing facile access to cyclohexene derivatives bearing two remote 1,6-related stereocenters. This distal stereocontrol methodology originates… read more here.
Keywords: carbonyl ene; desymmetrizing carbonyl; distant stereocenters; ene reaction ... See more keywords