Construction of a Pentacyclic Framework Enabled by Nickel Catalysis.
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DOI: 10.1021/acs.orglett.2c04228
Abstract: We present a novel nickel-catalyzed reaction of indole-tethered 2-alkynylphenol esters with various (hetero)aryl boronic acids, resulting in the synthesis of diversely functionalized pentacyclic benzofurocyclohepta[b]indole derivatives. This unprecedented cascade reaction involves the arylative cyclization of alkynes,… read more here.
Keywords: nickel catalysis; construction pentacyclic; framework enabled; enabled nickel ... See more keywords