Effect of Leptin Replacement Therapy (LRT) on Survival and Disease Progression in Generalized and Partial Lipodystrophy (GL, PL)
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DOI: 10.2337/db18-106-lb
Abstract: Lipodystrophy (LD) is an ultra-rare disease associated with significant morbidity and mortality. Effects of LRT on metabolic disease in GL and PL have been studied; but effects on mortality are unknown. We investigated these effects… read more here.
Keywords: consultant self; aegerion pharmaceuticals; self aegerion; mortality ... See more keywords
Triple vs. Dual Therapy with Low-Dose Dapagliflozin plus Saxagliptin vs. Each Monocomponent Added to Metformin in Uncontrolled Type 2 Diabetes
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DOI: 10.2337/db18-1149-p
Abstract: Triple therapy with dapagliflozin (DAPA) 10 mg/d + saxagliptin (SAXA) 5 mg/d added to metformin (MET) has greater efficacy than dual therapy in type 2 diabetes (T2D) inadequately controlled by MET alone. We tested triple… read more here.
Keywords: advisory panel; self; therapy; panel self ... See more keywords
Suppression of Ketogenesis in Type 1 Diabetes Is Not Delayed by SGLT2 Inhibitor Therapy
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DOI: 10.2337/db18-117-lb
Abstract: Enthusiasm for SGLT2 inhibitors as adjunctive agents for T1D has been tempered by increased risk of DKA, especially in pump treated patients susceptible to interruptions of basal insulin due to infusion site failures. Our insulin… read more here.
Keywords: ketogenesis; sglt2; ketogenesis type; suppression ketogenesis ... See more keywords
Baseline Characteristics of Participants in the Glycemia Reduction Approaches in Diabetes—A Comparative Effectiveness Study (GRADE)
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DOI: 10.2337/db18-1182-p
Abstract: GRADE is an NIDDK-sponsored, 36-center open-label randomized trial comparing the addition of one of the four most commonly used classes of glucose-lowering medications to metformin on long-term glycemic control and patient-centered outcomes in type 2… read more here.
Keywords: research; inc; novo nordisk; none ... See more keywords
Impact of SGLT2 Inhibitors (SGLT2i) on Cardiovascular (CV) Risk and Estimated Glomerular Filtration Rate (eGFR) in the EXSCEL Placebo Group
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DOI: 10.2337/db18-130-lb
Abstract: SGLT2i, empagliflozin and canagliflozin, have been shown to reduce the incidence of major adverse CV events (MACE), all-cause mortality (ACM) and renal events in CV outcomes trials (CVOTs), with robust real-world evidence (RWE) suggesting class… read more here.
Keywords: research; self astrazeneca; self; inc ... See more keywords
Diabetes Comorbidity and All-Cause, Cardiovascular, and Cancer Mortality in U.S. Adults
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DOI: 10.2337/db18-1580-p
Abstract: Type 2 diabetes is one of the most common chronic diseases in the U.S.; however, few studies have comprehensively assessed the relations between its comorbidities and premature death. Prospective analyses were performed linking data from… read more here.
Keywords: cause; mortality; cancer mortality; cancer ... See more keywords
Potential Autocrine Effects of Type 2 Diabetes–Related Myokines on Human Skeletal Muscle
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DOI: 10.2337/db18-1902-p
Abstract: Myokines are factors secreted by muscle cells that have been suggested to exert an array of autocrine, paracrine and/or endocrine actions. Secretion of a number of these myokines has been reported to be altered in… read more here.
Keywords: advisory panel; pharmaceuticals inc; self; panel self ... See more keywords
Twelve-Week Home Use of Hybrid Closed-Loop Insulin Delivery System vs. Sensor-Assisted Pump Therapy in Adults with Type 1 Diabetes—Intermediate Results of the Multicenter Randomised Crossover Diabeloop WP7 Trial
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DOI: 10.2337/db18-208-or
Abstract: Objective: Availability of closed-loop insulin delivery systems is expected by patients with type 1 diabetes. Our main objective was to assess whether patients using the Diabeloop artificial pancreas system could achieve a better glucose control… read more here.
Keywords: self abbott; self; closed loop; roche ... See more keywords
Increased HbA1c Variability May Shorten Time to Microalbuminuria Development in Type 1 Diabetes (T1D)
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DOI: 10.2337/db18-26-lb
Abstract: We aim to understand the impact of HbA1c variability, as measured by SD-HbA1c, on risk of microalbuminuria in T1D population. An analysis was performed utilizing data of 8,680 participants in the T1D Exchange Clinic Registry… read more here.
Keywords: hba1c; corporation; self; inc ... See more keywords
User Experience with a New Smartphone Application for Blood Glucose Monitoring (BGM) in an Information-Motivation-Behavioral Skills (IMB) Model Study
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DOI: 10.2337/db18-692-p
Abstract: The CONTOUR ® NEXT ONE BGM system (BGMS) includes a wireless-enabled BG meter that links to the CONTOUR ® Diabetes app installed on a mobile device. The system, based on the IMB model, detects and… read more here.
Keywords: self; support self; research support; consultant self ... See more keywords
Glycated Albumin Correlates Better with A1C than Fructosamine as a Marker of Intermediate Glycemic Control—A Multicenter Prospective Trial
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DOI: 10.2337/db18-919-p
Abstract: To evaluate the clinical utility of Glycated Albumin (GA) as an intermediate-term marker of glycemic control (preceding 2-3 weeks), we compared the correlation and concordance of GA and fructosamine (FRA) with A1C and mean blood… read more here.
Keywords: research support; pharmaceuticals inc; self; inc ... See more keywords