Kinetics of the coagulation cascade including the contact activation system: sensitivity analysis and model reduction
Sign Up to like & getrecommendations! Published in 2019 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-019-01134-4
Abstract: Thrombus formation is one of the main issues in the development of blood-contacting medical devices. This article focuses on the modeling of one aspect of thrombosis, the coagulation cascade, which is initiated by the contact… read more here.
Keywords: coagulation; coagulation cascade; model; sensitivity analysis ... See more keywords
Plasma contact activation by a fucosylated chondroitin sulfate and its structure–activity relationship study
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DOI: 10.1093/glycob/cwy067
Abstract: Plasma contact system is the initial part of both the intrinsic coagulation pathway and kallikrein-kinin pathway, which mainly involves three proteins: coagulation factor XII (FXII), prekallikrein (PK) and high-molecular weight kininogen. Fucosylated chondroitin sulfate (FCS)… read more here.
Keywords: plasma contact; contact activation; activation; chondroitin sulfate ... See more keywords
Contact activation and acquired von Willebrand syndrome during neonatal extracorporeal circulation
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DOI: 10.1111/jth.15058
Abstract: with APS and triple positivity are also positive in aPS/PT (tetra-positive aPL)7 and that aPS/PT more than aβ2GPI is responsible for LA activity in these patients.8 Finally, if aCL and aβ2GPI antibodies are of immunoglobulin… read more here.
Keywords: willebrand syndrome; syndrome neonatal; activation acquired; von willebrand ... See more keywords
The Effects of the Contact Activation System on Hemorrhage
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DOI: 10.3389/fmed.2017.00121
Abstract: The contact activation system (CAS) exerts effects on coagulation via multiple mechanisms, which modulate both the intrinsic and extrinsic coagulation cascades as well as fibrinolysis and platelet activation. While the effects of the CAS on… read more here.
Keywords: coagulation; ppk fxii; activation system; hemorrhage ... See more keywords
Cell Receptor and Cofactor Interactions of the Contact Activation System and Factor XI
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DOI: 10.3389/fmed.2018.00066
Abstract: The contact activation system (CAS) or contact pathway is central to the crosstalk between coagulation and inflammation and contributes to diverse disorders affecting the cardiovascular system. CAS initiation contributes to thrombosis but is not required… read more here.
Keywords: system; cell receptor; activation; cell ... See more keywords