Contact guidance diversity in rotationally aligned collagen matrices.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.11.039
Abstract: Cancer cell metastasis is responsible for approximately 90% of deaths related to cancer. The migration of cancer cells away from the primary tumor and into healthy tissue is driven in part by contact guidance, or… read more here.
Keywords: collagen; contact guidance; migration; guidance ... See more keywords
Cellular Contact Guidance on Liquid Crystalline Networks with Anisotropic Roughness
Sign Up to like & getrecommendations! Published in 2023 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.2c22892
Abstract: Cell contact guidance is widely employed to manipulate cell alignment and differentiation in vitro. The use of nano- or micro-patterned substrates allows efficient control of cell organization, thus opening up to biological models that cannot… read more here.
Keywords: cell; contact guidance; liquid crystalline;
Elucidating the signal for contact guidance contained in aligned fibrils with a microstructural–mechanical model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2021.0951
Abstract: Despite its importance in physiological processes and tissue engineering, the mechanism underlying cell contact guidance in an aligned fibrillar network has defied elucidation due to multiple interdependent signals that such a network presents to cells,… read more here.
Keywords: network; contact guidance; mechanical model; microstructural mechanical ... See more keywords
The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Autism"
DOI: 10.1186/s13229-019-0293-1
Abstract: BackgroundAlthough neuronal extracellular sensing is emerging as crucial for brain wiring and therefore plasticity, little is known about these processes in neurodevelopmental disorders. Ubiquitin protein ligase E3A (UBE3A) plays a key role in neurodevelopment. Lack… read more here.
Keywords: ligase e3a; contact guidance; guidance; role ... See more keywords
Individual cells generate their own self-reinforcing contact guidance cues through local matrix fiber remodeling
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0265403
Abstract: Directed cell migration arises from cells following a microenvironmental gradient (e.g. of a chemokine) or polarizing feature (e.g. a linear structure). However cells not only follow, but in many cases, also generate directionality cues by… read more here.
Keywords: individual cells; cell; contact guidance; relationship ... See more keywords