Functional role of glycosphingolipids in contact inhibition of growth in a human mammary epithelial cell line
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12709
Abstract: We have demonstrated previously the involvement of certain glycosphingolipids (GSLs) in ‘contact inhibition’ (dependent on cell‐to‐cell contact) of cell growth. Here, we examined the roles of specific GSLs in contact inhibition of the human epithelial… read more here.
Keywords: epithelial cell; cell line; inhibition; growth ... See more keywords
Directional Collective Migration in Wound Healing Assays.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7701-7_2
Abstract: Cell migration is suppressed by confluence in a process called contact inhibition. Relieving contact inhibition upon scratching is one of the simplest ways to induce cell migration in a variety of cell types. Wound healing… read more here.
Keywords: wound healing; directional collective; migration; collective migration ... See more keywords
Stochastic cellular automata model of neurosphere growth: Roles of proliferative potential, contact inhibition, cell death, and phagocytosis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2018.02.025
Abstract: Neural stem and progenitor cells isolated from the central nervous system form, under specific culture conditions, clonal cell clusters known as neurospheres. The neurosphere assay has proven to be a powerful in vitro system to… read more here.
Keywords: cell; model; proliferative potential; growth ... See more keywords
Metabolic and transcriptomic reprogramming during contact inhibition-induced quiescence is mediated by YAP-dependent and YAP-independent mechanisms
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-51117-y
Abstract: Metabolic rewiring during the proliferation-to-quiescence transition is poorly understood. Here, using a model of contact inhibition-induced quiescence, we conducted 13C-metabolic flux analysis in proliferating (P) and quiescent (Q) mouse embryonic fibroblasts (MEFs) to investigate this… read more here.
Keywords: inhibition induced; inhibition; contact inhibition; quiescence ... See more keywords
A neuroligin-2-YAP axis regulates progression of pancreatic intraepithelial neoplasia
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DOI: 10.1038/s44319-024-00104-x
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a tumor with a dismal prognosis that arises from precursor lesions called pancreatic intraepithelial neoplasias (PanINs). Progression from low- to high-grade PanINs is considered as tumor initiation, and a deeper… read more here.
Keywords: grade panins; high grade; grade; contact inhibition ... See more keywords
The Role of Mechanotransduction in Contact Inhibition of Locomotion and Proliferation
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25042135
Abstract: Contact inhibition (CI) represents a crucial tumor-suppressive mechanism responsible for controlling the unbridled growth of cells, thus preventing the formation of cancerous tissues. CI can be further categorized into two distinct yet interrelated components: CI… read more here.
Keywords: contact inhibition; locomotion; role mechanotransduction; locomotion proliferation ... See more keywords