Recent Trends in Advanced Contact Lenses.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201801390
Abstract: Exploiting contact lenses for ocular drug delivery is an emerging field in the area of biomedical engineering and advanced healthcare materials. Despite all the research conducted in this area, still, new technologies are in their… read more here.
Keywords: drug delivery; advanced contact; trends advanced; drug ... See more keywords
Controlled delivery of pirfenidone through vitamin E-loaded contact lens ameliorates corneal inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-018-0541-5
Abstract: Chemical injury by alkali burn is a major cause of corneal blindness in the clinical setting. Current management advocates multiple therapies aimed to prevent inflammation, initiate quick re-epithelialization, arrest the fibrosis, and avoid dry eye… read more here.
Keywords: vitamin loaded; delivery; drug; contact ... See more keywords
Micromechanical Measurement of Adhesion of Dehydrating Silicone Hydrogel Contact Lenses to Corneal Tissue.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.03.053
Abstract: Adhesion properties, which can vary with multiple factors, of silicone hydrogel contact lenses are important to their performance and comfort in the eye. In this study, we developed and used a simple, representative testing system… read more here.
Keywords: adhesive interactions; corneal tissue; adhesion; contact lenses ... See more keywords
Contact Lenses Coated with Hybrid Multifunctional Ternary Nanocoatings (Phytomolecule-coated ZnO nanoparticles:Gallic Acid:Tobramycin) for the Treatment of Bacterial and Fungal Keratitis.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.04.014
Abstract: Contact lenses are widely used for visual corrections. However, while wearing contact lenses, eyes typically face discomforts (itching, irritation, burning, etc.) due to foreign object sensation, lack of oxygen permeability, and tear film disruption as… read more here.
Keywords: acid tobramycin; gallic acid; nanoparticles gallic; contact ... See more keywords
Enhanced drug loading efficiency of contact lenses via salt-induced modulation
Sign Up to like & getrecommendations! Published in 2019 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2018.05.002
Abstract: Low drug loading efficiency is one of the main obstacles hindering the application of contact lenses (CLs) as the carrier for extended ocular drug delivery. Here in this study, a simple and effective drug loading… read more here.
Keywords: drug loading; salt; drug; loading efficiency ... See more keywords
Contact lenses with dual drug delivery for the treatment of bacterial conjunctivitis
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.06.059
Abstract: ABSTRACT Currently, bacterial conjunctivitis is treated by frequent administration of antibiotic eye drop solutions, which is tedious and patient noncompliant. Contact lenses could be ideal medical devices to sustain the release of ophthalmic drugs, but… read more here.
Keywords: drug; moxifloxacin hcl; contact; bacterial conjunctivitis ... See more keywords
Pigmented contact lenses for managing ocular disorders
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.11.052
Abstract: Graphical abstract Figure. No caption available. Abstract Blocking a selected wavelength range from the light spectrum can have multiple benefits. Ultra‐violet (UV) radiation is detrimental to the retina, necessitating its blocking through sunglasses and contact… read more here.
Keywords: managing ocular; visible light; contact lenses; pigmented contact ... See more keywords
In vitro and in vivo evaluation of cyclosporine-graphene oxide laden hydrogel contact lenses.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.121414
Abstract: Drug-eluting contact lens can substitute the multiple eye drop therapy. However, loading hydrophobic drug like cyclosporine in the contact lens is very challenging, due to low drug uptake (via soaking method); and alteration in the… read more here.
Keywords: contact lenses; cyclosporine; drug; laden contact ... See more keywords
Development of antibacterial contact lenses containing metallic nanoparticles
Sign Up to like & getrecommendations! Published in 2019 at "Polymer Testing"
DOI: 10.1016/j.polymertesting.2019.106034
Abstract: Abstract Background Contact lens wear can result in adverse events including bacterially-driven corneal infection and inflammation. These are the result of various kinds of bacteria adhering to contact lenses and either initiating infection of the… read more here.
Keywords: contact; pva; silver copper; spectroscopy ... See more keywords
High-Content Screening Discovers Microplastics Released by Contact Lenses under Sunlight.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental science & technology"
DOI: 10.1021/acs.est.3c01601
Abstract: The widespread use of plastic products leads to the ubiquity of microplastics in daily life, while the release of microplastics from long-used contact lenses has not been reported due to the limitations of conventional detection… read more here.
Keywords: released contact; contact lenses; contact; content screening ... See more keywords
In vitro Topical Delivery of Chlorhexidine to the Cornea: Enhancement using Drug-Loaded Contact Lenses and β-Cyclodextrin Complexation, and the Importance of Simulating Tear Irrigation.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c00140
Abstract: Keratitis is a severe, sight threatening condition caused by microbial infection. Eyedrops are the standard delivery medium for treating these disorders; however, blinking, elevated tear production and nasolacrimal drainage eliminates much of the instilled dose… read more here.
Keywords: drug loaded; delivery; drug; chlorhexidine ... See more keywords