Location of contact residues in pharmacologically distinct drug binding sites on P‐glycoprotein
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DOI: 10.1016/j.bcp.2016.10.002
Abstract: Graphical abstract Figure. No Caption available. Abstract The multidrug resistance P‐glycoprotein (P‐gp) is characterised by the ability to bind and/or transport an astonishing array of drugs. This poly‐specificity is imparted by at least four pharmacologically… read more here.
Keywords: drug binding; central cavity; contact residues; pharmacologically distinct ... See more keywords
Identification of Two Critical Contact Residues in a Pathogenic Epitope from Tetranectin for Monoclonal Antibody Binding and Preparation of Single-Chain Variable Fragments
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DOI: 10.3390/biom15081100
Abstract: Sepsis is a fetal disease that requires a clear diagnostic biomarker for timely antibiotic treatment. Recent research has identified a pyroptosis-inducing epitope known as P5-5 in tetranectin (TN), a plasma protein produced by monocytes. Previously,… read more here.
Keywords: monoclonal antibody; chain variable; contact residues; single chain ... See more keywords