The multifunctional nature of mitochondrial contact site proteins.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2020.02.010
Abstract: Mitochondria make physical contact with nearly every other membrane in the cell, and these contacts have a wide variety of functions that are carried out by proteins that reside at the sites of contact. Over… read more here.
Keywords: nature mitochondrial; mitochondrial contact; contact site; multifunctional nature ... See more keywords
Stepping outside the comfort zone of membrane contact site research
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-018-0022-1
Abstract: The past decade has seen striking progress in our understanding of communication between organelles via close appositions of their membranes, known as contact sites. Recent systematic studies highlight that the cellular contact site landscape is… read more here.
Keywords: membrane contact; contact sites; contact site; comfort zone ... See more keywords
LRRK1 functions as a scaffold for PTP1B-mediated EGFR sorting into ILVs at the ER–endosome contact site
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cell Science"
DOI: 10.1242/jcs.260566
Abstract: ABSTRACT Proper control of epidermal growth factor receptor (EGFR) signaling is important for maintaining cellular homeostasis. Given that EGFR signaling occurs at the plasma membrane and endosomes following internalization, endosomal trafficking of EGFR spatiotemporally regulates… read more here.
Keywords: egfr; contact site; ptp1b; endosome contact ... See more keywords
The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.260578
Abstract: Mitochondria are essential organelles of eukaryotic cells that are characterized by their unique and complex membrane system. They are confined from the cytosol by an envelope consisting of two membranes. Signals, metabolites, proteins and lipids… read more here.
Keywords: member; contact site; cqd1; membrane ... See more keywords
ER-PM membrane contact site regulation by yeast ORPs and membrane stress pathways
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010106
Abstract: In yeast, at least seven proteins (Ice2p, Ist2p, Scs2/22p, Tcb1-Tcb3p) affect cortical endoplasmic reticulum (ER) tethering and contact with the plasma membrane (PM). In Δ-super-tether (Δ-s-tether) cells that lack these tethers, cortical ER-PM association is… read more here.
Keywords: stress; tcb3p; membrane contact; membrane ... See more keywords
Podocalyxin Expressed in Antigen Presenting Cells Promotes Interaction With T Cells and Alters Centrosome Translocation to the Contact Site
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.835527
Abstract: Podocalyxin (PODXL), a cell surface sialomucin expressed in diverse types of normal and malignant cells, mediates cellular adhesion to extracellular matrix and cell-to-cell interaction. A previous study reported the expression of PODXL protein on monocytes… read more here.
Keywords: interaction; podocalyxin; podxl; antigen presenting ... See more keywords