Analysis of cold activation of the contact system in hereditary angioedema with normal C1 inhibitor.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular immunology"
DOI: 10.1016/j.molimm.2021.06.009
Abstract: Hereditary angioedema (HAE) attacks are caused by excessive activation of the contact system. Understanding how the contact system is activated in HAE, especially in patients with normal C1 inhibitor (HAEnCI), is essential to effectively treat… read more here.
Keywords: contact system; system activation; system; cold activation ... See more keywords
Electrodynamic Forces in a High Voltage Circuit Breakers With Tulip Contact System—FEM Simulations
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Access"
DOI: 10.1109/access.2022.3207768
Abstract: Paper concerns the effects of electrodynamic forces that act on the contacts of the tulip contact system that is often implemented in high voltage circuit breakers. The high voltage circuit breaker often consists of two… read more here.
Keywords: system; high voltage; circuit; contact ... See more keywords
Design and characterization of α1-antitrypsin variants for treatment of contact system-driven thromboinflammation.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood.2019000481
Abstract: The contact system produces the inflammatory peptide bradykinin and contributes to experimental thrombosis. C1 esterase-inhibitor (C1INH) deficiency or gain-of-function mutations in Factor XII (FXII) cause hereditary angioedema, a life-threatening tissue swelling disease. C1INH is a… read more here.
Keywords: system; system driven; antitrypsin; treatment contact ... See more keywords
Anti-HK antibody reveals critical roles of a 20-residue HK region for Aβ-induced plasma contact system activation
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021006612
Abstract: Key Points A 20-residue region in domain 6 of HK plays a critical role in Aβ42-induced contact system activation. 3E8 blocks PK and FXI binding to HK, disassembles HK/PK and HK/FXI complexes, and delays intrinsic… read more here.
Keywords: residue region; system activation; contact system;
Targeting the contact system in a rabbit model of extracorporeal membrane oxygenation
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2022007586
Abstract: Key Points • Factors XII and XI drive thrombosis in ECMO. FXII appears to promote organ damage in ECMO independent of thrombin generation.• Thrombin-mediated activation of FXI may overshadow the role of FXII in ECMO… read more here.
Keywords: contact system; targeting contact; rabbit model; system rabbit ... See more keywords
Forming regimes of Pd/Ge/Au contact system to n-GaAs influence on its electric parameters
Sign Up to like & getrecommendations! Published in 2023 at "Technical Physics Letters"
DOI: 10.21883/tpl.2023.02.55361.19409
Abstract: The investigations of Pd/Ge/Au contact system forming regimes influence on the specific contact resistivity to n-type conductivity GaAs layer were carried out. The method of samples surface treatment before the layers evaporation and thermal annealing… read more here.
Keywords: system; regimes contact; influence; contact system ... See more keywords
Virulence Associated Gene 8 of Bordetella pertussis Enhances Contact System Activity by Inhibiting the Regulatory Function of Complement Regulator C1 Inhibitor
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01172
Abstract: Bordetella pertussis is a Gram-negative bacterium and the causative agent of whooping cough. Whooping cough is currently re-emerging worldwide and, therefore, still poses a continuous global health threat. B. pertussis expresses several virulence factors that… read more here.
Keywords: system; virulence; contact system; complement ... See more keywords