Could Previous Exposure to Nitrogen‐Containing Bisphosphonates Mitigate Friendly Fire?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4163
Abstract: We read with great interest the article by Sing and colleagues. The authors conducted a nicely designed cohort study using a nationwide database and concluded that nitrogen-containing bisphosphonates (N-BPs) are protective against pneumonia. Alendronate and… read more here.
Keywords: previous exposure; containing bisphosphonates; nitrogen containing; could previous ... See more keywords
Hydroxamate-Containing Bisphosphonates as Fosmidomycin Analogues: Design, Synthesis, and Proherbicide Activity.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c07872
Abstract: Fosmidomycin (FOS) is a natural product inhibiting the DXR enzyme in the MEP pathway and has stimulated interest for finding more suitable FOS analogues. Herein, two series of FOS analogue hydroxamate-containing bisphosphonates as proherbicides were… read more here.
Keywords: containing bisphosphonates; series; hydroxamate; hydroxamate containing ... See more keywords
Augmentation of the cytotoxic effects of nitrogen‐containing bisphosphonates in hypoxia
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DOI: 10.1111/jphp.12934
Abstract: Tumour hypoxia is a major obstacle in cancer therapy that leads to poor prognosis. Therefore, the development of cancer treatments that are effective in hypoxia is necessary. Nitrogen‐containing bisphosphonates (N‐BPs), which are used to treat… read more here.
Keywords: cytotoxic effects; effects nitrogen; containing bisphosphonates; augmentation cytotoxic ... See more keywords
The Cellular and Mitochondrial Consequences of Mevalonate Pathway Inhibition by Nitrogen-Containing Bisphosphonates: A Narrative Review
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DOI: 10.3390/ph18071029
Abstract: Nitrogen-containing bisphosphonates (N-BPs) are commonly used drugs in the treatment of bone diseases due to their potent inhibition of the mevalonate pathway, leading to disrupted protein prenylation and reduced osteoclast activity. Although N-BPs are effective… read more here.
Keywords: bps; mevalonate pathway; containing bisphosphonates; energy metabolism ... See more keywords
Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates
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DOI: 10.7554/elife.36620
Abstract: Nitrogen-containing-bisphosphonates (N-BPs) are a class of drugs widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies have established that N-BPs function by inhibiting the mevalonate pathway in osteoclasts, the mechanism by which… read more here.
Keywords: transporter complex; identification transporter; containing bisphosphonates; nitrogen containing ... See more keywords