Fragment-based discovery of sulfur-containing diarylbenzopyrimidines as novel nonnucleoside reverse transcriptase inhibitors
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DOI: 10.1016/j.cclet.2019.11.020
Abstract: Abstract Two series of sulfur-containing diarylbenzopyrimidines are designed by the fragment combination of a thioacetamide with our previous disclosed DABP 3 and further oxidation. The best compound 6e with a sulfonyl scaffold displayed EC50 values… read more here.
Keywords: containing diarylbenzopyrimidines; discovery; sulfur containing; reverse transcriptase ... See more keywords