PROTACs bearing piperazine-containing linkers: what effect on their protonation state?
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra03761k
Abstract: Proteolysis targeting chimeras (PROTACs) represent an emerging class of compounds for innovative therapeutic application. Their bifunctional nature induces the formation of a ternary complex (target protein/PROTAC/E3 ligase) which allows target protein ubiquitination and subsequent proteasomal-dependent… read more here.
Keywords: containing linkers; effect; piperazine containing; protonation ... See more keywords