Identification of human flavin-containing monooxygenase 3 substrates by a colorimetric screening assay.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2017.01.024
Abstract: Human hepatic flavin-containing monooxygenase 3 is a phase I drug-metabolizing enzyme that is responsible for the oxidation of a variety of drugs and xenobiotics. This work reports on a high throughput rapid colorimetric assay for… read more here.
Keywords: containing monooxygenase; identification human; flavin containing; assay ... See more keywords
Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114763
Abstract: Out of the five isoforms of human flavin-containing monooxygenase (hFMO), FMO1 and FMO3 are the most relevant to Phase I drug metabolism. They are involved in the oxygenation of xenobiotics including drugs and pesticides using… read more here.
Keywords: flavin containing; human flavin; containing monooxygenase; hydroperoxyflavin intermediate ... See more keywords
Genetic variants of flavin-containing monooxygenase 3 (FMO3) derived from Japanese subjects with the trimethylaminuria phenotype and whole-genome sequence data from a large Japanese database.
Sign Up to like & getrecommendations! Published in 2019 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2019.06.001
Abstract: Flavin-containing monooxygenase 3 (FMO3) is a polymorphic xenobiotic- and dietary compound-metabolizing enzyme associated with the genetic disorder trimethylaminuria. We phenotyped 428 Japanese subjects using traditional urinary phenotyping assays and identified two subjects with read more here.
Keywords: containing monooxygenase; flavin containing; monooxygenase fmo3; database ... See more keywords
Expression and metabolic activity of flavin‐containing monooxygenase 1 in cynomolgus macaque kidney
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Primatology"
DOI: 10.1111/jmp.12385
Abstract: Flavin‐containing monooxygenase 1 (FMO1) largely remains to be characterized in cynomolgus macaque kidney. Immunoblotting showed expression of cynomolgus FMO1 in kidneys where activities of FMO1 (benzydamine N‐oxygenation) were detected. No sex differences were observed in… read more here.
Keywords: containing monooxygenase; flavin containing; cynomolgus macaque; cynomolgus ... See more keywords
Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0187294
Abstract: Busulphan (Bu) is an alkylating agent used in the conditioning regimen prior to hematopoietic stem cell transplantation (HSCT). Bu is extensively metabolized in the liver via conjugations with glutathione to form the intermediate metabolite (sulfonium… read more here.
Keywords: containing monooxygenase; metabolic pathway; flavin containing; tht ... See more keywords