Inhibition of GluN2D-Containing NMDA Receptors Protects Dopaminergic Neurons against 6-OHDA-Induced Neurotoxicity via Activating ERK/NRF2/HO-1 Signaling.
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DOI: 10.1021/acschemneuro.3c00608
Abstract: Abnormal glutamate signaling is implicated in the heightened vulnerability of dopaminergic neurons in Parkinson's disease (PD). NMDA receptors are ion-gated glutamate receptors with high calcium permeability, and their GluN2D subunits are prominently distributed in the… read more here.
Keywords: nmda receptors; glun2d; erk nrf2; dopaminergic neurons ... See more keywords
The GluN3-containing NMDA receptors
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DOI: 10.1080/19336950.2025.2490308
Abstract: ABSTRACT N-methyl-D-aspartate receptors (NMDARs) are heterotetrameric ion channels that play crucial roles in brain function. Among all the NMDAR subtypes, GluN1-N3 receptors exhibit unique agonist binding and gating properties. Unlike “conventional” GluN1-N2 receptors, which require… read more here.
Keywords: nmda receptors; glun1 receptors; brain; containing nmda ... See more keywords
Bidentatide, a Novel Plant Peptide Derived from Achyranthes bidentata Blume: Isolation, Characterization, and Neuroprotection through Inhibition of NR2B-Containing NMDA Receptors
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DOI: 10.3390/ijms22157977
Abstract: Increasing attention is being focused on the use of polypeptide-based N-methyl-d-aspartate (NMDA) receptor antagonists for the treatment of nervous system disorders. In our study on Achyranthes bidentata Blume, we identified an NMDA receptor subtype 2B… read more here.
Keywords: peptide; achyranthes bidentata; inhibition; bidentata blume ... See more keywords