Downregulation of WW domain-containing oxidoreductase leads to tamoxifen-resistance by the inactivation of Hippo signaling
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Biology and Medicine"
DOI: 10.1177/1535370219854678
Abstract: Acquired tamoxifen-resistance is an important cause of death in patients with hormone-dependent breast tumors. Therefore, understanding the molecular mechanisms underlying the development of tamoxifen-resistance is critical for successful endocrine therapy. This study aimed to define… read more here.
Keywords: domain containing; containing oxidoreductase; resistance; tamoxifen resistance ... See more keywords
Recurrent alterations of the WW domain containing oxidoreductase gene spanning the common fragile site FRA16D in multiple myeloma and monoclonal gammopathy of undetermined significance.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology letters"
DOI: 10.3892/ol.2017.6672
Abstract: The putative tumor suppressor gene WW domain containing oxidoreductase (WWOX) spans a common fragile site (CFS) on chromosome 16q23.3. CFSs are regions of profound genomic instability and sites for genomic deletions in cancer cells. Therefore,… read more here.
Keywords: domain containing; methylation; containing oxidoreductase; multiple myeloma ... See more keywords