DeepSecMS Advances DIA‐Based Selenoproteome Profiling Through Cys‐to‐Sec Proxy Training
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202504109
Abstract: Selenoproteins, defined as proteins containing the 21st amino acid, selenocysteine (Sec, U), are functionally important but rare, with only 25 selenoproteins characterized in the entire human proteome to date. To comprehensively analyze selenoproteomes, previously developed… read more here.
Keywords: cys; deepsecms; proxy training; sec ... See more keywords
Identification and preparation of selenium-containing peptides from selenium-enriched Pleurotus eryngii and their protective effect on lead-induced oxidative damage in NCTC1469 hepatocytes.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12529
Abstract: BACKGROUND Lead (Pb) is a highly toxic and persistent substance that easily accumulates in living organisms, eliciting cellular toxicity and oxidative stress. Some selenium-containing proteins and peptides prepared from plant extracts are beneficial for protecting… read more here.
Keywords: selenium containing; selenium enriched; enriched pleurotus; induced oxidative ... See more keywords
Interaction Mechanism and Clustering among RGD Peptides and Integrins
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Informatics"
DOI: 10.1002/minf.201600069
Abstract: Peptides with an exposed arginine–glycine–aspartate (Arg–Gly–Asp, RGD) sequence targeting the integrin αVβ3 play an important role in targeted anticancer drug delivery. The interaction of multiple RGD‐containing peptides and two αVβ3 molecules was studied via MD… read more here.
Keywords: rgd containing; interaction mechanism; interaction; containing peptides ... See more keywords
Identification of β‐aminopyrrolidine containing peptides as β‐amyloid aggregation inhibitors for Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Peptide Science"
DOI: 10.1002/psc.3386
Abstract: Alzheimer's disease (AD) is caused by a series of events initiated by the production and aggregation of the amyloid β‐protein (Aβ). In the early stages of the disease, Aβ is released in a soluble form… read more here.
Keywords: identification aminopyrrolidine; aggregation; alzheimer disease; aminopyrrolidine containing ... See more keywords
Effects of tryptophan-containing peptides on angiotensin-converting enzyme activity and vessel tone ex vivo and in vivo
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Nutrition"
DOI: 10.1007/s00394-016-1374-y
Abstract: PurposeOver-activation of the renin-angiotensin axis and worsening of vascular function are critical contributors to the development of hypertension. Therefore, inhibition of angiotensin-converting enzyme (ACE), a key factor of the renin-angiotensin axis, is a first line… read more here.
Keywords: vivo; tryptophan containing; vessel tone; containing peptides ... See more keywords
Cysteine-Containing Peptides Stimulate Monocyte Migration through NADPH-Oxidase Activation
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-017-3766-2
Abstract: We analyzed migration of monocytes under the effect of apocinin (NADPH inhibitor) and PD98059 (blocker of extracellular MEK/ERK kinase involved in Nox4 oxidase-mediated migration of monocytes). Migration of monocytes stimulated by cysteine-containing peptides (fragments of… read more here.
Keywords: oxidase; migration; containing peptides; monocyte migration ... See more keywords
Selenium Decipher: Trapping of Native Selenomethionine-Containing Peptides in Selenium-Enriched Milk and Unveiling the Deterioration after Ultrahigh-Temperature Treatment.
Sign Up to like & getrecommendations! Published in 2024 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.3c04247
Abstract: Selenopeptide identification relies on databases to interpret the selenopeptide spectra. A common database search strategy is to set selenium as a variable modification instead of sulfur on peptides. However, this approach generally detects only a… read more here.
Keywords: selenium; selenium decipher; selenomethionine containing; selenium enriched ... See more keywords
Arginine-Containing Peptides Derived from Walnut Protein Against Cognitive and Memory Impairment in Scopolamine-Induced Zebrafish: Design, Release, and Neuroprotection.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c05104
Abstract: The purpose of this study was to investigate the neuroprotective effect of Arg-containing peptides from walnut storage protein sequences in scopolamine-induced zebrafish and further to validate the potential neuroprotection of Arg-containing peptide enriched walnut hydrolysates… read more here.
Keywords: neuroprotection; arg containing; induced zebrafish; scopolamine induced ... See more keywords
Lower Diversity of Amylase-Trypsin Inhibitors and Ex Vivo-Released Opioid-Containing Peptides in Ancestral Compared to Modern Wheat Varieties Assessed by Proteomics and Peptidomics
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Agricultural and Food Chemistry"
DOI: 10.1021/acs.jafc.4c05959
Abstract: This study focused on identifying amylase-trypsin inhibitors (ATIs) in seven Norwegian-cultivated wheat varieties, including common wheat and ancestral species, and identifying potentially harmful opioid peptides within the ex vivo digesta of these wheats. LC–MS/MS analysis… read more here.
Keywords: opioid containing; wheat varieties; wheat; containing peptides ... See more keywords
Enriching Cysteine-Containing Peptides Using a Sulfhydryl-Reactive Alkylating Reagent with a Phosphonic Acid Group and Immobilized Metal Affinity Chromatography.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00806
Abstract: The reduction of disulfide bonds and their subsequent alkylation are commonplace in typical proteomics workflows. Here, we highlight a sulfhydryl-reactive alkylating reagent with a phosphonic acid group (iodoacetamido-LC-phosphonic acid, 6C-CysPAT) that facilitates the enrichment of… read more here.
Keywords: phosphonic acid; containing peptides; sulfhydryl reactive; reactive alkylating ... See more keywords
Structure–Activity Relationships of RGD-Containing Peptides in Integrin αvβ5-Mediated Cell Adhesion
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c06540
Abstract: The RGD motif is a cell adhesion sequence that binds to integrins, a receptor family for extracellular matrix proteins. We previously reported that the RGDX1X2 sequence, where X1X2 is VF or NY, is required for… read more here.
Keywords: adhesion; cell adhesion; containing peptides; mediated cell ... See more keywords