Articles with "containing r882h" as a keyword



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Preferential self-interaction of DNA methyltransferase DNMT3A subunits containing the R882H cancer mutation leads to dominant changes of flanking sequence preferences.

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Published in 2022 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2022.167482

Abstract: Somatic R882H DNMT3A mutations occur frequently in AML, but their pathogenic mechanism is unclear. As R882H mutations usually are heterozygous, wildtype (WT) and R882H subunits co-exist in affected cells. R882 is located in the RD… read more here.

Keywords: containing r882h; flanking sequence; dnmt3a; sequence preferences ... See more keywords