Design, Synthesis and Biological Evaluation of Novel 4-phenoxypyridine Derivatives Containing Semicarbazones Moiety as Potential c-Met Kinase Inhibitors.
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DOI: 10.2174/1871520620666200101143307
Abstract: BACKGROUND The Hepatocyte Growth Factor Receptor (HGFR) c-Met is over-expressed and/or mutated in various human tumor types. Dysregulation of c-Met/HGF signaling pathway affects cell proliferation, survival and motility, leading to tumor growth, angiogenesis, and metastasis.… read more here.
Keywords: containing semicarbazones; phenoxypyridine derivatives; derivatives containing; met kinase ... See more keywords