Use of the High-Content Imaging System equipment to evaluate in vitro infection by Leishmania braziliensis in response to sand fly Nyssomyia neivai saliva.
Sign Up to like & getrecommendations! Published in 2020 at "Acta tropica"
DOI: 10.1016/j.actatropica.2020.105540
Abstract: Earlier research has shown that in vivo immunization with sand fly saliva protects the host against infection by parasites of genus Leishmania, and inoculation of saliva along with Leishmania promastigotes favors infection in the host.… read more here.
Keywords: sand fly; infection; content imaging; high content ... See more keywords
High Content Imaging of Barrett’s-Associated High-Grade Dysplasia Cells After siRNA Library Screening Reveals Acid-Responsive Regulators of Cellular Transitions
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2020.05.002
Abstract: Background & Aims Esophageal adenocarcinoma (EAC) develops from within Barrett’s esophagus (BE) concomitant with gastroesophageal reflux disease (GERD). Wound healing processes and cellular transitions, such as epithelial–mesenchymal transitions, may contribute to the development of BE… read more here.
Keywords: high grade; library screening; content imaging; cellular transitions ... See more keywords
Cell culture conditions affect the ability of high content imaging assay to detect drug-induced changes in cellular parameters in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology Reports"
DOI: 10.1016/j.toxrep.2019.02.004
Abstract: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are widely used for drug safety and efficacy testing with various techniques, including high content imaging (HCI). Upon drug treatment, a significant number of hiPSC-CMs grown in regular… read more here.
Keywords: high content; content imaging; drug; cell ... See more keywords
High-content imaging analyses of the effects of bisphenols and organophosphate esters on TM4 mouse Sertoli cells
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac101
Abstract: Abstract The endocrine disruptive effects of bisphenol A (BPA) and brominated flame retardants (BDE-47) have led to restrictions on their use and increased the pressure to identify safe replacements for these chemicals. Although there is… read more here.
Keywords: content imaging; high content; sertoli cells; organophosphate esters ... See more keywords
Abstract 4694: Evaluation of tumor-associated antigen expression with the MACSimaTMhigh-content imaging platform
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-4694
Abstract: Here we report the use of the MACSima™ imaging platform to perform high-content imaging for the pre-clinical validation of tumor target expression on tumor and healthy human tissues indicative for potential on-target/off-tumor toxicity in vivo.… read more here.
Keywords: expression; imaging platform; tumor; content imaging ... See more keywords
Abstract LB113: Bio-printed 3D cell models and high-content imaging for testing anti-cancer compounds
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb113
Abstract: The discovery and screening of anti-cancer drugs is a vast field that is constantly evolving. More advanced cell-based models are needed to have an efficient way of studying cellular and subcellular effects of compound treatments,… read more here.
Keywords: anti cancer; content imaging; high content; printed cell ... See more keywords
In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air–Liquid Interface Cultures
Sign Up to like & getrecommendations! Published in 2020 at "SLAS Technology"
DOI: 10.1177/2472630319895473
Abstract: High-content imaging (HCI) is a powerful method for quantifying biological effects in vitro. Historically, HCI has been applied to adherent cells growing in monolayers. With the advent of confocal versions of HCI devices, researchers now… read more here.
Keywords: organotypic air; content imaging; bronchial organotypic; liquid interface ... See more keywords
Hepatic Organoid-Based High-Content Imaging Boosts Evaluation of Stereoisomerism-Dependent Hepatotoxicity of Stilbenes in Herbal Medicines
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.862830
Abstract: The complexity of chemical components of herbal medicines often causes great barriers to toxicity research. In our previous study, we have found the critical divergent hepatotoxic potential of a pair of stilbene isomers in a… read more here.
Keywords: evaluation; herbal medicines; content imaging; high content ... See more keywords
Optimized High-Content Imaging Screening Quantifying Micronuclei Formation in Polymer-Treated HaCaT Keratinocytes
Sign Up to like & getrecommendations! Published in 2022 at "Nanomaterials"
DOI: 10.3390/nano12244463
Abstract: Research on nano- and micro-plastic particles (NMPPs) suggests their potential threat to human health. Some studies have even suggested genotoxic effects of NMPP exposure, such as micronuclei (MN) formation, while others found the opposite. To… read more here.
Keywords: micronuclei formation; content imaging; optimized high; high content ... See more keywords