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   Articles with "contextual fear" as a keyword



Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning

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recommendations! Published in 2018 at "Psychopharmacology"

DOI: 10.1007/s00213-018-5162-7

Abstract: RationaleDopamine D1 receptor (D1R) signalling is involved in contextual fear conditioning. The D1R antagonist SCH23390 impairs the acquisition of contextual fear when administered systemically or infused locally into the dorsal hippocampus or basolateral amygdala.ObjectivesWe determined… read more here.

Keywords: fear; fear conditioning; sch23390; dorsomedial prefrontal ... See more keywords
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The mTORC1 inhibitor rapamycin and the mTORC1/2 inhibitor AZD2014 impair the consolidation and persistence of contextual fear memory

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recommendations! Published in 2020 at "Psychopharmacology"

DOI: 10.1007/s00213-020-05573-1

Abstract: The mechanistic target of rapamycin (mTOR) kinase mediates various long-lasting forms of synaptic and behavioural plasticity. However, there is little information concerning the temporal pattern of mTOR activation and susceptibility to pharmacological intervention during consolidation… read more here.

Keywords: consolidation; inhibitor; fear memory; persistence ... See more keywords
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Individual expression of conditioned safety but not of conditioned relief is correlated with contextual fear

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recommendations! Published in 2020 at "Behavioural Brain Research"

DOI: 10.1016/j.bbr.2020.112799

Abstract: Stimuli that are either presented directly after or explicitly unpaired to an aversive event can be associated with the relief or absence of the aversive event. Such stimuli then become conditioned stimuli (CS) for relief… read more here.

Keywords: relief; expression conditioned; safety; conditioned relief ... See more keywords

Corticosterone impairs contextual fear recall after reactivation in the ovariectomized rat model of menopause

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recommendations! Published in 2020 at "Behavioural Brain Research"

DOI: 10.1016/j.bbr.2020.112817

Abstract: Menopause affects most physiological processes, including cognitive functions, although, the extent to which these functions are affected is not clear. The aim of this study was to investigate the effect of corticosterone (CORT) administration after… read more here.

Keywords: fear recall; model menopause; reactivation; rat model ... See more keywords

Alcohol exposure and environmental enrichment effects on contextual fear conditioning in zebrafish

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recommendations! Published in 2022 at "Behavioural Processes"

DOI: 10.1016/j.beproc.2022.104608

Abstract: Environmental enrichment effectively reduces anxiety-like indicators in animals, a potential co-treatment for diseases that generate variations in basal anxiety, such as alcoholism. Here we present an experimental design that allows investigating the effect of enrichment… read more here.

Keywords: anxiety; environmental enrichment; alcohol; contextual fear ... See more keywords

Oxytocin receptor antagonist atosiban impairs consolidation, but not reconsolidation of contextual fear memory in rats

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recommendations! Published in 2018 at "Brain Research"

DOI: 10.1016/j.brainres.2018.05.034

Abstract: There is increasing evidence that oxytocin is involved in learning and memory process. This study investigated the effects of blockade of oxytocin receptors using the selective oxytocin receptor antagonist atosiban (ATO) on contextual fear memory… read more here.

Keywords: contextual fear; memory; consolidation reconsolidation; fear memory ... See more keywords

Nicotine modulates contextual fear extinction through changes in ventral hippocampal GABAergic function

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recommendations! Published in 2018 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2018.08.019

Abstract: ABSTRACT Numerous studies have attributed the psychopathology of anxiety and stress disorders to maladaptive behavioral responses such as an inability to extinguish fear. Therefore, understanding neural substrates of fear extinction is imperative for developing more… read more here.

Keywords: nicotine; extinction; ventral hippocampal; fear extinction ... See more keywords

Disrupting the hippocampal Piwi pathway enhances contextual fear memory in mice

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recommendations! Published in 2019 at "Neurobiology of Learning and Memory"

DOI: 10.1016/j.nlm.2019.04.002

Abstract: The Piwi pathway is a conserved gene regulatory mechanism comprised of Piwi-like proteins and Piwi-interacting RNAs, which modulates gene expression via RNA interference and through interaction with epigenetic mechanisms. The mammalian Piwi pathway has been… read more here.

Keywords: fear memory; piwi pathway; contextual fear; piwi ... See more keywords

Effects of hippocampal IP3R inhibition on contextual fear memory consolidation, retrieval, reconsolidation and extinction

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recommendations! Published in 2022 at "Neurobiology of Learning and Memory"

DOI: 10.1016/j.nlm.2022.107587

Abstract: Intracellular calcium stores (ICS) play a dynamic role in neuronal calcium (Ca2+) homeostasis both by buffering Ca2+ excess in the cytoplasm or providing an additional source of Ca2+ when concentration increase is needed. However, in… read more here.

Keywords: memory; contextual fear; memory consolidation; fear memory ... See more keywords

The Possible Role of Neurobeachin in Extinction of Contextual Fear Memory

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-30589-1

Abstract: Established fear memory becomes vulnerable to disruption after memory retrieval and extinction; this labile state is critical for inhibiting the return of fear memory. However, the labile state has a very narrow time window after… read more here.

Keywords: memory retrieval; extinction; fear memory; contextual fear ... See more keywords

Endocannabinoids inhibit contextual fear memory generalization via hippocampal GABAergic synaptic transmission.

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2423974122

Abstract: Memory generalization allows an organism to adapt to new conditions, but overgeneralization of fear or traumatic experiences can be detrimental to survival and contributes to the development of various mental disorders. However, the cellular and… read more here.

Keywords: contextual fear; memory; fear memory; memory generalization ... See more keywords