The metaplastic effects of ketamine on sucrose renewal and contextual memory reconsolidation in rats
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.112347
Abstract: Metaplastic effects of the NMDARs blocker ketamine at the neural and behavioural levels have been described as potential mechanisms underlying the beneficial effects in treatment-resistant depression. However, ketamine effects on addictive behaviours are still unexplored.… read more here.
Keywords: memory reconsolidation; renewal; metaplastic effects; reconsolidation ... See more keywords
Ventro-dorsal Hippocampal Pathway Gates Novelty-Induced Contextual Memory Formation
Sign Up to like & getrecommendations! Published in 2021 at "Current Biology"
DOI: 10.1016/j.cub.2020.09.074
Abstract: Summary Novelty facilitates memory formation and is detected by both the dorsal and ventral hippocampus. Although dentate granule cells (GCs) in the dorsal hippocampus are known to mediate the formation of novelty-induced contextual memories, the… read more here.
Keywords: memory formation; induced contextual; formation; contextual memory ... See more keywords
Modulation of dorsal hippocampal SK2 channels regulates morphine-enhanced neuronal oscillations and morphine-induced contextual memory encoding and retrieval
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-24819-6
Abstract: Persistent maladaptive drug-context associations are a key component of relapse vulnerability and pose a major obstacle in treating opioid use disorder. Although the dorsal hippocampus (dHPC) is critical for contextual memory formation, the synaptic mechanisms… read more here.
Keywords: dorsal; memory; morphine; contextual memory ... See more keywords
Glutamatergic basolateral amygdala to anterior insular cortex circuitry maintains rewarding contextual memory
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-0862-z
Abstract: Findings have shown that anterior insular cortex (aIC) lesions disrupt the maintenance of drug addiction, while imaging studies suggest that connections between amygdala and aIC participate in drug-seeking. However, the role of the BLA → aIC pathway… read more here.
Keywords: anterior insular; insular cortex; rewarding contextual; bla aic ... See more keywords
Retrieval of contextual memory can be predicted by CA3 remapping and is differentially influenced by NMDAR activity in rat hippocampus subregions
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002706
Abstract: Episodic memory is essential to navigate in a changing environment by recalling past events, creating new memories, and updating stored information from experience. Although the mechanisms for acquisition and consolidation have been profoundly studied, much… read more here.
Keywords: retrieval; memory; nmdar activity; contextual memory ... See more keywords
Morphine modulates hippocampal neurogenesis and contextual memory extinction via miR-34c/Notch1 pathway in male ICR mice
Sign Up to like & getrecommendations! Published in 2020 at "Open Life Sciences"
DOI: 10.1515/biol-2020-0006
Abstract: Abstract Background The opioid Morphine is known to affect neurogenesis in the hippocampus. Evidence has shown that several microRNAs modulate morphine-induced neurogenesis, and hence morphine-induced contextual memory. This complex network has yet to be elucidated.… read more here.
Keywords: morphine induced; morphine; hippocampal neurogenesis; contextual memory ... See more keywords
Activation of Gs Signaling in Cortical Astrocytes Does Not Influence Formation of a Persistent Contextual Memory Engram
Sign Up to like & getrecommendations! Published in 2024 at "eNeuro"
DOI: 10.1523/eneuro.0056-24.2024
Abstract: Formation and retrieval of remote contextual memory depends on cortical engram neurons that are defined during learning. Manipulation of astrocytic Gq and Gi associated G-protein coupled receptor (GPCR) signaling has been shown to affect memory… read more here.
Keywords: signaling cortical; memory; cortical engram; engram neurons ... See more keywords
Transient Prepubertal Mifepristone Treatment Normalizes Deficits in Contextual Memory and Neuronal Activity of Adult Male Rats Exposed to Maternal Deprivation
Sign Up to like & getrecommendations! Published in 2017 at "eNeuro"
DOI: 10.1523/eneuro.0253-17.2017
Abstract: Abstract Early life adversity is a well-known risk factor for behavioral dysfunction later in life, including the formation of contextual memory; it is also (transiently) accompanied by hyperactivity of the stress system. We tested whether… read more here.
Keywords: male rats; treatment; rats exposed; adult male ... See more keywords
Impairing of Serotonin Synthesis by P-Chlorphenylanine Prevents the Forgetting of Contextual Memory After Reminder and the Protein Synthesis Inhibition
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00607
Abstract: HIGHLIGHTS The injection of p-chlorophenylalanine, specific blocker of 5-HT synthesis 3 days before reminder with anisomycin administration prevented forgetting. It is known that the reminder cause reactivation of the long-term memory and it leads to… read more here.
Keywords: protein; synthesis; reconsolidation; contextual memory ... See more keywords
Cellular and circuit features distinguish mouse dentate gyrus semilunar granule cells and granule cells activated during contextual memory formation
Sign Up to like & getrecommendations! Published in 2025 at "eLife"
DOI: 10.7554/elife.101428
Abstract: The dentate gyrus is critical for spatial memory formation and shows task-related activation of cellular ensembles considered as memory engrams. Semilunar granule cells (SGCs), a sparse dentate projection neuron subtype, were reported to be enriched… read more here.
Keywords: dentate; contextual memory; memory; memory formation ... See more keywords