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Published in 2021 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202100491
Abstract: An oxidative NHC-catalyzed kinetic resolution (KR) of racemic mixtures is presented. The developed reaction furnishes tricyclic dihydropyranones with three contiguous stereocenters in excellent dia- and enantioselectivity, with good-to-moderate yields. Mechanistic studies indicate that the rate-determining…
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Keywords:
three contiguous;
kinetic resolution;
dihydropyranones three;
catalyzed kinetic ... See more keywords
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Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra07390g
Abstract: A modular and scalable strategy, which remodels 3-methylglutaric anhydride to 2-oxopiperidines bearing at least three contiguous stereocenters is described. The approach relies on the chemoselective and stereocontrolled annulation of 1,3-azadienes with the anhydride component. The…
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Keywords:
leveraging azadiene;
reaction synthesis;
synthesis functionalized;
azadiene anhydride ... See more keywords