Integrated Continuous Biomanufacturing: Industrialization on the Horizon
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DOI: 10.1002/biot.201800722
Abstract: Continuous bioprocessing has the inherent advantage of higher productivity, which can facilitate implementation of small process trains resulting in cost-effective, lean, and agile manufacturing facilities. Impressive technological advances to enable continuous bioprocessing have been made… read more here.
Keywords: continuous bioprocessing; industrialization horizon; biomanufacturing industrialization; continuous biomanufacturing ... See more keywords
A common framework for integrated and continuous biomanufacturing
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DOI: 10.1002/bit.27690
Abstract: There is a growing application of integrated and continuous bioprocessing (ICB) for manufacturing recombinant protein therapeutics produced from mammalian cells. At first glance, the newly evolved ICB has created a vast diversity of platforms. A… read more here.
Keywords: continuous biomanufacturing; framework; common framework; integrated continuous ... See more keywords
The design basis for the integrated and continuous biomanufacturing framework
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DOI: 10.1002/bit.27697
Abstract: An 8 ton per year manufacturing facility is described based on the framework for integrated and continuous bioprocessing (ICB) common to all known biopharmaceutical implementations. While the output of this plant rivals some of the largest… read more here.
Keywords: continuous biomanufacturing; framework; basis integrated; design basis ... See more keywords
Predictive modeling of single pass tangential flow filtration for continuous biomanufacturing.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology progress"
DOI: 10.22541/au.164133555.56141274/v1
Abstract: Opportunities for process intensification have made continuous biomanufacturing an area of active research. While tangential flow filtration (TFF) is typically employed within the biologics purification train to increase drug substance concentration, single-pass TFF (SPTFF) modifies… read more here.
Keywords: single pass; concentration; flow; continuous biomanufacturing ... See more keywords